Rome2Rio

How to get fromSt. Louis to Greenvilleby plane, bus (Amtrak, Flixbus), car, taxi, or bus (Greyhound, Flixbus)

Find Transport to Greenville

See all options

There are 6 ways to get from St. Louis to Greenville by plane, bus (Amtrak, Flixbus), car, taxi, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP)plane plane STL - GSP
    4h 59m
    $158–748

  2. Drive 648 mi

    cheapest
    1. Drive from St. Louis to Greenvillecar car 648 mi
    11h 3m
    $119–171

  3. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    16h 20m
    $149–348

  4. Fly to Asheville Regional Airport, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Asheville Regional Airport (AVL)plane plane STL - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    6h 12m
    $232–652

  5. Fly to Columbia, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Columbia (CAE)plane plane STL - CAE
    2. Drive from Columbia-Airport-CAE to Greenvillecar car
    7h 10m
    $250–1,330

  6. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus Charlotte
    16h 55m
    $148–333

Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP) flights

Calendar126Weekly Planes
Duration4h 44mAverage Duration
Ticket$122Cheapest Price
See schedules

Questions & Answers

Map of how to get from St. Louis to Greenville.ExpandLaunch map view
  • Distance: 549.3 mi
  • Duration: 4h 59m

What companies run services between St. Louis, MO, USA and Greenville, SC, USA?

Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP) hourly. Alternatively, you can take a bus from St. Louis to Greenville via Carbondale Intermodal Station, Atlanta Bus Station, Garnett Station, Doraville Station, Atlanta, and Taqueria Guadalajara - Greenville in around 16h 20m.

Airlines
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers