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How to get fromSt. Louis to Griffithby train (Amtrak), bus (Flixbus), car, plane, train, taxi, or bus

Find Transport to Griffith

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There are 7 ways to get from St. Louis to Griffith by train (Amtrak), bus (Flixbus), car, plane, train, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Van Buren St. to Gary/Chicago Airporttrain train Lakeshore / ...
    6h 22m
    $190–279

  2. Drive  285 mi

    cheapest
    1. Drive from St. Louis to Griffithcar car 285 mi
    5h 14m
    $52–76

  3. Bus (Flixbus)

    1. Take the bus from St Louis Bus Station to Chicagobus bus FlixBus N2521
    7h 37m
    $85–120

  4. Fly Lambert–St. Louis International Airport to Chicago Midway International Airport, train, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Van Buren St. to Gary/Chicago Airporttrain train
    3. Take the taxi from Gary/Chicago Airport to Griffithtaxi taxi
    4h 34m
    $86–394

  5. Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport, train, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the train from Van Buren St. to Gary/Chicago Airporttrain train
    3. Take the taxi from Gary/Chicago Airport to Griffithtaxi taxi
    5h 3m
    $306–744

  6. Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport, train

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane plane SPI - ORD
    3. Take the train from Van Buren St. to Gary/Chicago Airporttrain train
    6h 15m
    $129–370

  7. Bus to Decatur Airport, fly to Chicago O'Hare International Airport, train

    1. Take the bus from St Louis Bus Station to Decatur Downtown Transportation Centerbus bus
    2. Fly from Decatur Airport (DEC) to Chicago O'Hare International Airport (ORD)plane plane DEC - ORD
    3. Take the train from Van Buren St. to Gary/Chicago Airporttrain train
    6h 59m
    $98–320

Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW) flights

Calendar32Weekly Planes
Duration1h 6mAverage Duration
Ticket$51Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Griffith.ExpandLaunch map view
  • Distance: 315.7 mi
  • Duration: 6h 22m

What companies run services between St. Louis, MO, USA and Griffith, IN, USA?

You can take a train from St. Louis to Griffith via Chicago Union Station, Jackson & Clinton, Michigan & Van Buren/Ida B. Wells, Van Buren St., and Gary/Chicago Airport in around 6h 22m. Alternatively, Flixbus USA operates a bus from St Louis Bus Station to Chicago 5 times a week. Tickets cost $45–75 and the journey takes 5h 40m.

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