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How to get fromSt. Louis to Guelphby plane, train, train (Amtrak), bus (Greyhound, Flixbus), car, shuttle, or bus

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There are 9 ways to get from St. Louis to Guelph by plane, train, train (Amtrak), bus (Greyhound, Flixbus), car, shuttle, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Toronto Pearson International Airport, train

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Pearson International Airport (YYZ)plane plane STL - YYZ
    2. Take the train from Bramalea GO to Guelph Central GOtrain train
    7h 2m
    $767–1,921

  2. Bus

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis, IN to Detroit, MIbus bus
    3. Take the bus from Detroit Bus Station to Kitchenerbus bus
    18h 21m
    $138–281

  3. Train

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Port Huron Stationtrain train
    3. Take the train from Sarnia to Guelphtrain train
    17h 26m
    $316–799

  4. Drive 1,129.8 km

    1. Drive from St. Louis to Guelphcar car 1,129.8 km
    12h 15m
    $224–324

  5. Fly to Toronto Island Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Island Airport (YTZ)plane plane STL - YTZ
    2. Take the train from Union Station GO to Guelph Central GOtrain train
    8h 54m
    $667–1,422

  6. Fly to Buffalo Niagara International Airport, shuttle, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    2. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle bus
    3. Take the train from Bramalea GO to Guelph Central GOtrain train
    10h
    $347–1,381

  7. Fly to London International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to London International Airport (YXU)plane plane STL - YXU
    2. Take the train from London to Guelphtrain train
    12h 2m
    $320–1,729

  8. Fly to Detroit, shuttle, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Detroit (DTW)plane plane STL - DTW
    2. Take a shuttle bus from Detroit Airport to London, ON - 105, Wharncliffe Road South, Manor Parkshuttle bus
    3. Take the train from London to Guelphtrain train
    11h
    $640–1,656

  9. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the bus from Chicago Union Station to Port Huron Stationbus bus
    3. Take the train from Sarnia to Guelphtrain train
    17h 26m
    $346–759

St. Louis to Guelph by train and car

Calendar7Weekly Services
Duration17h 26mAverage Duration
Ticket$316Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Guelph.ExpandLaunch map view
  • Distance: 1,136.1 km
  • Duration: 7h 2m

What companies run services between St. Louis, MO, USA and Guelph, ON, Canada?

You can take a train from St. Louis to Guelph via Chicago Union Station, Port Huron Station, and Sarnia in around 17h 26m. Alternatively, you can take a bus from St Louis Bus Station to Guelph Central GO Bus via Indianapolis, IN, Detroit Bus Station, Kitchener, Victoria / Duke, Lackner / Victoria, and Victoria St. N. @ Lackner Blvd. in around 18h 21m.

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