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How to get fromSt. Louis to Iowaby plane, bus (Greyhound), train, bus, car, or bus (Flixbus, Amtrak, Greyhound)

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There are 7 ways to get from St. Louis to Iowa by plane, bus (Greyhound), train, bus, car, or bus (Flixbus, Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Omaha

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Omaha (OMA)plane plane STL - OMA
    3h 1m
    $628–932

  2. Drive 331.1 mi

    cheapest
    1. Drive from St. Louis to Des Moinescar car 331.1 mi
    6h 35m
    $61–88

  3. Bus via Kansas City

    1. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus Greyhound US0180s / ...
    2. Take the bus from Kansas City to Des Moinesbus bus Jefferson Lines 804 / ...
    8h 25m
    $85–141

  4. Train, bus

    1. Take the train from St. Louis to Kansas Citytrain train Missouri River Runner / ...
    2. Take the bus from Kansas City to Des Moinesbus bus Jefferson Lines 804 / ...
    10h 51m
    $125–239

  5. Fly to Des Moines

    1. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane plane STL - DSM
    5h 22m
    $140–724

  6. Fly to Quad City International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Quad City International Airport (MLI)plane plane STL - MLI
    6h 43m
    $70–404

  7. Bus

    1. Take the bus from St Louis Bus Station to Springfield SMTD Transfer Centerbus bus
    2. Take the bus from Springfield to Galesburg Amtrak Stationbus bus
    3. Take the bus from Galesburg to Des Moinesbus bus
    11h 36m
    $88–140

St. Louis to Iowa by bus

Calendar18Weekly Buses
Duration8h 25mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Iowa.ExpandLaunch map view
  • Distance: 364 mi
  • Duration: 3h 1m

What companies run services between St. Louis, MO, USA and Iowa, USA?

Southwest Airlines flies from Lambert–St. Louis International Airport (STL) to Omaha (OMA) twice daily. Alternatively, you can take a bus from St Louis Bus Station to Des Moines via Kansas City Bus Station and Kansas City in around 8h 25m.

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