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How to get fromSt. Louis to Irontonby bus, train, bus (Greyhound), car, or plane

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There are 6 ways to get from St. Louis to Ironton by bus, train, bus (Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train Cardinal
    12h 1m
    $138–269

  2. Drive 452.3 mi

    cheapest
    1. Drive from St. Louis to Irontoncar car 452.3 mi
    7h 34m
    $83–120

  3. Bus

    1. Take the bus from St Louis Bus Station to Columbusbus bus Greyhound US0421
    2. Take the bus from Columbus to Ashland Bus Stationbus bus Greyhound US0140
    12h 56m
    $92–191

  4. Fly to Tri-State Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Tri-State Airport (HTS)plane plane STL - HTS
    7h 17m
    $138–598

  5. Fly to Yeager Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Yeager Airport (CRW)plane plane STL - CRW
    2. Take the train from Charleston Station to Ashland Amtrak Stationtrain train
    8h 45m
    $152–634

  6. Fly to John Glenn Columbus International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to John Glenn Columbus International Airport (CMH)plane plane STL - CMH
    2. Take the bus from Columbus to Ashland Bus Stationbus bus
    7h 22m
    $130–752

Lambert–St. Louis International Airport (STL) to Tri-State Airport (HTS) flights

Calendar15Weekly Planes
Duration6hAverage Duration
Ticket$106Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Ironton.ExpandLaunch map view
  • Distance: 518.6 mi
  • Duration: 12h 1m

What companies run services between St. Louis, MO, USA and Ironton, OH, USA?

You can take a bus from St Louis Bus Station to Ironton via Columbus and Ashland Bus Station in around 12h 56m. Alternatively, American Airlines and Southwest Airlines fly from Lambert–St. Louis International Airport (STL) to Tri-State Airport (HTS) twice daily.

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