There are 4 ways to get from St. Louis to Jacksonville by plane, bus (Greyhound, Flixbus), car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Jacksonville
best- Fly from Lambert–St. Louis International Airport (STL) to Jacksonville (JAX)plane STL - JAX
5h 14m$88–476Bus
- Take the bus from St Louis Bus Station to Atlanta Bus Stationbus Greyhound US0186
- Take the bus from Atlanta Bus Station to Jacksonvillebus FlixBus N2434 / ...
19h 15m$160–257Drive 859.6 mi
- Drive from St. Louis to Jacksonvillecar 859.6 mi
15h 10m$142–205Fly to Brunswick Golden Isles Airport, bus
- Fly from Lambert–St. Louis International Airport (STL) to Brunswick Golden Isles Airport (BQK)plane STL - BQK
- Take the bus from Brunswick to Jacksonvillebus
7h 31m$114–498
St. Louis to Jacksonville by bus
Comparing Your Travel Options
The cheapest way to get from St. Louis to Jacksonville is to drive which costs $140 - $210 and takes 15h 10m.
The fastest way to get from St. Louis to Jacksonville is to fly which takes 5h 14m and costs $85 - $480.
No, there is no direct bus from St. Louis station to Jacksonville. However, there are services departing from St Louis Bus Station and arriving at Jacksonville via Atlanta Bus Station. The journey, including transfers, takes approximately 19h 15m.
The distance between St. Louis and Jacksonville is 790 miles. The road distance is 864.6 miles.
The best way to get from St. Louis to Jacksonville without a car is to bus which takes 19h 15m and costs $160 - $260.
It takes approximately 5h 14m to get from St. Louis to Jacksonville, including transfers.
St. Louis to Jacksonville bus services, operated by Greyhound USA, depart from St Louis Bus Station.
The best way to get from St. Louis to Jacksonville is to fly which takes 5h 14m and costs $85 - $480. Alternatively, you can bus, which costs $160 - $260 and takes 19h 15m.
St. Louis to Jacksonville bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Jacksonville is 1h ahead of St. Louis. It is currently 1:55 PM in St. Louis and 2:55 PM in Jacksonville.
What companies run services between St. Louis, MO, USA and Jacksonville, FL, USA?
Southwest Airlines, Delta, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Jacksonville (JAX) every 3 hours. Alternatively, you can take a bus from St Louis Bus Station to Jacksonville via Atlanta Bus Station in around 19h 15m.
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Jacksonville via Atlanta
- Ave. Duration
- 4h 11m
- When
- Every day
- Estimated price
- $85–470
Flights from Lambert–St. Louis International Airport to Brunswick Golden Isles Airport via Atlanta
- Ave. Duration
- 4h 58m
- When
- Every day
- Estimated price
- $85–460
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Jacksonville
- Ave. Duration
- 1h 57m
- When
- Every day
- Estimated price
- $85–470
Flights from Lambert–St. Louis International Airport to Jacksonville via Nashville
- Ave. Duration
- 3h 51m
- When
- Every day
- Estimated price
- $85–480
Flights from Lambert–St. Louis International Airport to Jacksonville via Chicago Midway
- Ave. Duration
- 4h 32m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $110–550
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Jacksonville via Charlotte
- Ave. Duration
- 4h 31m
- When
- Every day
- Estimated price
- $95–500
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 11h 40m
- Frequency
- Once daily
- Estimated price
- $95–150
- Website
- Greyhound
Bus from Atlanta Bus Station to Jacksonville
- Ave. Duration
- 8h 55m
- Frequency
- Twice daily
- Estimated price
- $65–110
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from St Louis Bus Station to Atlanta Bus Station
- Ave. Duration
- 10h 10m
- Frequency
- 5 times a week
- Estimated price
- $95–140
- Schedules at
- Flixbus USA
Bus from Atlanta Bus Station to Jacksonville
- Ave. Duration
- 6h 35m
- Frequency
- 3 times a day
- Estimated price
- $65–95
- Schedules at
- Flixbus USA
Bus from Brunswick to Jacksonville
- Ave. Duration
- 1h 15m
- Frequency
- 5 times a week
- Estimated price
- $11–17
- Schedules at
- Flixbus USA
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Booking & Getting There
Yes, the driving distance between St. Louis to Jacksonville is 865 miles. It takes approximately 15h 10m to drive from St. Louis to Jacksonville.
Book your St. Louis to Jacksonville bus tickets online with Omio and FlixBus.
There are 641+ hotels available in Jacksonville.