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How to get fromSt. Louis to Jacksonvilleby plane, bus (Greyhound, Flixbus), train, bus, or car

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There are 7 ways to get from St. Louis to Jacksonville by plane, bus (Greyhound, Flixbus), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Albert J. Ellis Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Albert J. Ellis Airport (OAJ)plane plane STL - OAJ
    6h 7m
    $132–592

  2. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Raleigh Bus Stationbus bus
    3. Take the bus from Raleigh Bus Station to Jacksonville Bus Stopbus bus
    25h 11m
    $166–325

  3. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the bus from Raleigh Bus Station to Jacksonville Bus Stopbus bus
    35h 39m
    $458–992

  4. Drive 882.8 mi

    1. Drive from St. Louis to Jacksonvillecar car 882.8 mi
    16h 22m
    $162–233

  5. Fly to Wilmington International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Wilmington International Airport (ILM)plane plane STL - ILM
    2. Take the bus from Wilmington Amtrak Station to Jacksonville Amtrak Bus Stopbus bus
    7h 53m
    $132–594

  6. Fly to Coastal Carolina Regional Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Coastal Carolina Regional Airport (EWN)plane plane STL - EWN
    2. Take the bus from New Bern to Jacksonville Bus Stopbus bus
    7h 36m
    $140–680

  7. Bus, train

    1. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Downtown to Durhambus bus
    4. Take the train from Durham Amtrak Station to Wilsontrain train
    5. Take the bus from Wilson to Jacksonville Amtrak Bus Stopbus bus
    27h 52m
    $231–411

St. Louis to Jacksonville by bus

Calendar14Weekly Buses
Duration25h 11mAverage Duration
Ticket$166Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Jacksonville.ExpandLaunch map view
  • Distance: 783.1 mi
  • Duration: 6h 7m

What companies run services between St. Louis, MO, USA and Jacksonville, NC, USA?

Delta and American Airlines fly from Lambert–St. Louis International Airport (STL) to Albert J. Ellis Airport (OAJ) every 4 hours. Alternatively, you can take a bus from St Louis Bus Station to Jacksonville Bus Stop via Atlanta Bus Station and Raleigh Bus Station in around 25h 11m.

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