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How to get fromSt. Louis to Jeffersonvilleby bus (Greyhound), car, or plane

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There are 4 ways to get from St. Louis to Jeffersonville by bus (Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus Greyhound US0185 / ...
    2. Take the bus from Evansville, IN to Louisville, KYbus bus Evansville / ...
    7h 41m
    $63–110

  2. Drive 261.3 mi

    cheapest
    1. Drive from St. Louis to Jeffersonvillecar car 261.3 mi
    4h 19m
    $48–69

  3. Fly to Louisville International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    7h 14m
    $104–608

  4. Fly to Blue Grass Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    2. Drive from Lexington-Airport-LEX to Jeffersonvillecar car
    6h 51m
    $196–1,022

St. Louis to Jeffersonville by bus and foot

Calendar14Weekly Services
Duration7h 41mAverage Duration
Ticket$63Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Jeffersonville.ExpandLaunch map view
  • Distance: 288.4 mi
  • Duration: 7h 41m

What companies run services between St. Louis, MO, USA and Jeffersonville, IN, USA?

You can take a bus from St Louis Bus Station to Court @ Spring via Evansville, IN, Louisville, KY, Chestnut @ 13th, Chestnut @ 8th, and Liberty @ Roy Wilkins in around 7h 41m. Alternatively, Southwest Airlines, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) hourly.

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