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How to get fromSt. Louis to Key Westby plane, bus (Greyhound, Flixbus), car, bus, train, or ferry

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There are 5 ways to get from St. Louis to Key West by plane, bus (Greyhound, Flixbus), car, bus, train, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Lambert–St. Louis International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Key West International Airport (EYW)plane plane STL - EYW
    6h 22m
    $108–466

  2. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    33h 6m
    $193–378

  3. Drive 1,350.2 mi

    1. Drive from St. Louis to Key Westcar car 1,350.2 mi
    23h 43m
    $247–356

  4. Fly from Midamerica St. Louis Airport

    1. Fly from Midamerica St. Louis Airport (BLV) to Key West International Airport (EYW)plane plane BLV - EYW
    19h 1m
    $112–414

  5. Bus, train, ferry

    1. Take the bus from St Louis Bus Station to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    3. Take the bus from Gulfport to Fort Myersbus bus
    4. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    38h 32m
    $412–567

St. Louis to Key West by bus and foot

Calendar12Weekly Services
Duration33h 6mAverage Duration
Ticket$193Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Key West.ExpandLaunch map view
  • Distance: 1,118 mi
  • Duration: 6h 22m

What companies run services between St. Louis, MO, USA and Key West, FL, USA?

Delta, American Airlines, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from St Louis Bus Station to N Roosevelt & 3rd Street via Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 33h 6m.

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