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How to get fromSt. Louis to Knoxvilleby plane, bus (Greyhound), train, bus, or car

Find Transport to Knoxville

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There are 7 ways to get from St. Louis to Knoxville by plane, bus (Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    5h 16m
    $198–972

  2. Drive  481.4 mi

    cheapest
    1. Drive from St. Louis to Knoxvillecar car 481.4 mi
    7h 58m
    $88–127

  3. Bus

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    38h 22m
    $354–518

  4. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 40m
    $837–1,340

  5. Fly to Nashville, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    5h 30m
    $182–802

  6. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Chattanooga Metropolitan Airport (CHA)plane plane STL - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    6h 34m
    $96–460

  7. Train, bus via Ossining

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 16m
    $802–1,217

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar123Weekly Planes
Duration4h 42mAverage Duration
Ticket$144Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Knoxville.ExpandLaunch map view
  • Distance: 431.5 mi
  • Duration: 5h 16m

What companies run services between St. Louis, MO, USA and Knoxville, TN, USA?

Delta, Southwest Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from St Louis Bus Station to Knoxville via Port Authority Bus Terminal, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 38h 22m.

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