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How to get fromSt. Louis to Knoxville Airport (TYS)by plane, car, bus (Greyhound, Flixbus), train, bus, bus (Greyhound), or rideshare

Find Transport to Knoxville Airport (TYS)

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There are 9 ways to get from St. Louis to Knoxville Airport (TYS) by plane, car, bus (Greyhound, Flixbus), train, bus, bus (Greyhound), or rideshare

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Mcghee Tyson Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    5h 30m
    $122–752

  2. Drive 482.4 mi

    cheapest
    1. Drive from St. Louis to Knoxville Airport (TYS)car car 482.4 mi
    8h
    $88–128

  3. Fly Lambert–St. Louis International Airport to Nashville, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    2. Drive from Nashville-Airport-BNA to Knoxville-Airport-TYScar car
    5h 32m
    $112–652

  4. Bus via Nashville

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville, TN to New York, NYbus bus Ny
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 4m
    $310–402

  5. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    39h 53m
    $553–1,028

  6. Fly Lambert–St. Louis International Airport to Chattanooga Metropolitan Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Chattanooga Metropolitan Airport (CHA)plane plane STL - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxville-Airport-TYScar car
    6h 58m
    $180–930

  7. Fly Midamerica St. Louis Airport to Mcghee Tyson Airport

    1. Fly from Midamerica St. Louis Airport (BLV) to Mcghee Tyson Airport (TYS)plane plane BLV - TYS
    15h 35m
    $236–980

  8. Bus

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York to Knoxvillebus bus Nyc
    38h 29m
    $347–552

  9. Airport Transfer

    1. Take the rideshare from St. Louis to Knoxville-TYSrideshare rideshare 482.4 mi
    8h

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

Calendar113Weekly Planes
Duration5h 2mAverage Duration
Ticket$128Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Knoxville Airport (TYS).ExpandLaunch map view
  • Distance: 418.7 mi
  • Duration: 5h 30m

What companies run services between St. Louis, MO, USA and Knoxville Airport (TYS), USA?

Delta, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) hourly. Alternatively, you can take a bus from St Louis Bus Station to Knoxville Airport (TYS) via Nashville Bus Station, Fulton Station Outbound, Nashville, TN, New York, NY, and Knoxville, TN in around 36h 4m.

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