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How to get fromSt. Louis to Knoxvilleby train, bus, car, plane, taxi, or bus (Flixbus, Amtrak)

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There are 6 ways to get from St. Louis to Knoxville by train, bus, car, plane, taxi, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus (Amtrak)

    best
    1. Take the train from St. Louis to Springfieldtrain train Lincoln Service / ...
    2. Take the bus from Springfield to Galesburg Amtrak Stationbus bus Amtrak Thruway Connecting Service
    5h 1m
    $85–141

  2. Drive 178.9 mi

    cheapest
    1. Drive from St. Louis to Knoxvillecar car 178.9 mi
    4h 29m
    $33–48

  3. Train, bus via Bloomington

    1. Take the train from St. Louis to Bloomington-Normaltrain train Lincoln Service / ...
    2. Take the bus from Bloomington-Normal to Galesburgbus bus Greyhound US0157S
    5h 16m
    $81–152

  4. Fly to Quad City International Airport, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Quad City International Airport (MLI)plane plane STL - MLI
    2. Take the taxi from Moline-Airport-MLI to Knoxvilletaxi taxi
    6h 15m
    $202–582

  5. Bus

    1. Take the bus from St Louis Bus Station to Springfield SMTD Transfer Centerbus bus FlixBus N2521 / ...
    2. Take the bus from Springfield to Galesburg Amtrak Stationbus bus Amtrak Thruway Connecting Service
    5h 44m
    $72–106

  6. Fly to Peoria International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Peoria International Airport (PIA)plane plane STL - PIA
    2. Take the bus from Peoria Amtrak Station to Galesburg Amtrak Stationbus bus
    8h 35m
    $102–470

Lambert–St. Louis International Airport (STL) to Quad City International Airport (MLI) flights

Calendar107Weekly Planes
Duration5h 3mAverage Duration
Ticket$70Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Knoxville.ExpandLaunch map view
  • Distance: 219.1 mi
  • Duration: 5h 1m

What companies run services between St. Louis, MO, USA and Knoxville, IL, USA?

You can take a bus from St Louis Bus Station to Knoxville via Springfield SMTD Transfer Center, Transfer Center Stop B, Jefferson & 4th, Springfield, and Galesburg Amtrak Station in around 5h 44m.

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