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How to get fromSt. Louis to La Crosseby plane, train (Amtrak), train, bus, car, or bus (Flixbus, Greyhound)

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There are 6 ways to get from St. Louis to La Crosse by plane, train (Amtrak), train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to La Crosse (LSE)plane plane STL - LSE
    5h 36m
    $96–466

  2. Drive 437.1 mi

    cheapest
    1. Drive from St. Louis to La Crossecar car 437.1 mi
    8h 15m
    $80–116

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    10h 54m
    $181–373

  4. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to La Crossebus bus
    12h 31m
    $151–293

  5. Fly to Minneapolis–Saint Paul International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    7h 29m
    $424–1,040

  6. Bus

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to La Crossebus bus
    13h 22m
    $120–190

St. Louis to La Crosse by train (Amtrak)

Calendar21Weekly Trains
Duration10h 54mAverage Duration
Ticket$181Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to La Crosse.ExpandLaunch map view
  • Distance: 379.1 mi
  • Duration: 5h 36m

What companies run services between St. Louis, MO, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Lambert–St. Louis International Airport (STL) to La Crosse (LSE) every 4 hours. Alternatively, you can take a train from St. Louis to La Crosse Amtrak Station via Chicago Union Station in around 10h 54m.

Airlines
Train operators
Bus operators

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