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How to get fromSt. Louis to Lafayetteby bus (Greyhound, Amtrak), train (Amtrak), car, plane, bus, train, bus (Greyhound), or shuttle

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There are 9 ways to get from St. Louis to Lafayette by bus (Greyhound, Amtrak), train (Amtrak), car, plane, bus, train, bus (Greyhound), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Lafayette Amtrak Stationbus bus
    6h 45m
    $51–115

  2. Drive 253.4 mi

    cheapest
    1. Drive from St. Louis to Lafayettecar car 253.4 mi
    4h 58m
    $47–67

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    8h 56m
    $126–265

  4. Fly to Purdue University Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Purdue University Airport (LAF)plane plane STL - LAF
    5h 58m
    $68–414

  5. Bus, train

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the train from Indianapolis to Lafayette Amtrak Stationtrain train Cardinal
    7h 1m
    $61–120

  6. Bus via Indianapolis Airport (IND)

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Airport to Courtyard Lafayettebus bus Indianapolis
    7h 51m
    $65–107

  7. Fly to Indianapolis, shuttle

    1. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    2. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    6h 37m
    $116–688

  8. Fly to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 33m
    $98–460

  9. Fly to Chicago O'Hare International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 54m
    $310–788

St. Louis to Lafayette by bus

Calendar14Weekly Buses
Duration6h 45mAverage Duration
Ticket$51Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Lafayette.ExpandLaunch map view
  • Distance: 306.1 mi
  • Duration: 6h 45m

What companies run services between St. Louis, MO, USA and Lafayette, IN, USA?

You can take a bus from St Louis Bus Station to Lafayette Amtrak Station via Indianapolis Union Station in around 6h 45m. Alternatively, you can take a train from St. Louis to Lafayette Amtrak Station via Chicago Union Station in around 8h 56m.

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