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How to get fromSt. Louis to Lafayetteby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 6 ways to get from St. Louis to Lafayette by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Lafayette Regional Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Lafayette Regional Airport (LFT)plane plane STL - LFT
    5h 47m
    $124–566

  2. Bus

    1. Take the bus from St Louis Bus Station to Baton Rouge Bus Stationbus bus Greyhound US1173
    2. Take the bus from Baton Rouge Bus Station to Lafayettebus bus FlixBus 2211 / ...
    20h 25m
    $127–241

  3. Bus, train

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the train from Carbondale to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Lafayette Amtrak Stationtrain train
    21h 17m
    $261–566

  4. Drive 706.2 mi

    1. Drive from St. Louis to Lafayettecar car 706.2 mi
    11h 55m
    $129–187

  5. Fly to Louis Armstrong New Orleans International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Louis Armstrong New Orleans International Airport (MSY)plane plane STL - MSY
    2. Take the bus from New Orleans International Airport to Lafayette Transit Systembus bus
    7h 54m
    $424–948

  6. Fly to Lake Charles Regional Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Lake Charles Regional Airport (LCH)plane plane STL - LCH
    2. Take the bus from Lake Charles to Lafayettebus bus
    8h 17m
    $154–626

St. Louis to Lafayette by bus

Calendar7Weekly Buses
Duration20h 25mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Lafayette.ExpandLaunch map view
  • Distance: 613.5 mi
  • Duration: 5h 47m

What companies run services between St. Louis, MO, USA and Lafayette, LA, USA?

Delta, United Airlines, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Lafayette Regional Airport (LFT) every 2 hours. Alternatively, you can take a bus from St Louis Bus Station to Lafayette via Baton Rouge Bus Station in around 20h 25m.

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