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How to get fromSt. Louis to Lafayette Stationby bus (Greyhound), train (Amtrak), car, plane, bus (Flixbus), shuttle, or train

Find Transport to Lafayette Station

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There are 8 ways to get from St. Louis to Lafayette Station by bus (Greyhound), train (Amtrak), car, plane, bus (Flixbus), shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Lafayette Bus Stopbus bus Greyhound US0120S / ...
    7h 24m
    $50–78

  2. Drive  252.7 mi

    cheapest
    1. Drive from St. Louis to Lafayette Stationcar car 252.7 mi
    4h 57m
    $47–67

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    8h 56m
    $219–347

  4. Fly to Purdue University Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Purdue University Airport (LAF)plane plane STL - LAF
    6h 11m
    $64–384

  5. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from St Louis Bus Station to Chicagobus bus FlixBus N2521
    2. Take the bus from Chicago to Lafayette Bus Stopbus bus FlixBus N2640 / ...
    9h 9m
    $62–93

  6. Fly to Indianapolis, shuttle

    1. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    2. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    6h 54m
    $876–938

  7. Fly to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 29m
    $120–458

  8. Fly to Chicago O'Hare International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 58m
    $392–820

St. Louis to Lafayette Station by bus and foot (Greyhound)

Calendar21Weekly Services
Duration7h 24mAverage Duration
Ticket$50Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Lafayette Station.ExpandLaunch map view
  • Distance: 306.9 mi
  • Duration: 7h 24m

What companies run services between St. Louis, MO, USA and Lafayette Station, IN, USA?

You can take a bus from St Louis Bus Station to Lafayette Station via Indianapolis Union Station and Lafayette Bus Stop in around 7h 24m. Alternatively, you can take a train from St. Louis to Lafayette Amtrak Station via Chicago Union Station in around 8h 56m.

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