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How to get fromSt. Louis to Lafayette Stationby bus (Greyhound), train (Amtrak), car, plane, bus, train, bus (Flixbus, Amtrak), or shuttle

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There are 9 ways to get from St. Louis to Lafayette Station by bus (Greyhound), train (Amtrak), car, plane, bus, train, bus (Flixbus, Amtrak), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Lafayette Bus Stopbus bus Greyhound US0100 / ...
    6h 54m
    $48–91

  2. Drive 252.7 mi

    cheapest
    1. Drive from St. Louis to Lafayette Stationcar car 252.7 mi
    4h 57m
    $47–67

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    8h 56m
    $126–263

  4. Fly to Purdue University Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Purdue University Airport (LAF)plane plane STL - LAF
    6h 1m
    $74–414

  5. Bus, train

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the train from Indianapolis to Lafayette Amtrak Stationtrain train Cardinal
    7h 1m
    $62–122

  6. Bus via Champaign

    1. Take the bus from St Louis Bus Station to Champaign Intermodal Trans Ctrbus bus
    2. Take the bus from Champaign to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Lafayette Amtrak Stationbus bus
    8h 45m

  7. Fly to Indianapolis, shuttle

    1. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    2. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    6h 44m
    $116–638

  8. Fly to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 33m
    $98–450

  9. Fly to Chicago O'Hare International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    7h 54m
    $310–788

St. Louis to Lafayette Station by bus and foot

Calendar42Weekly Services
Duration6h 54mAverage Duration
Ticket$48Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Lafayette Station.ExpandLaunch map view
  • Distance: 305.6 mi
  • Duration: 6h 54m

What companies run services between St. Louis, MO, USA and Lafayette Station, IN, USA?

You can take a bus from St Louis Bus Station to Lafayette Station via Indianapolis Union Station and Lafayette Bus Stop in around 6h 54m. Alternatively, you can take a train from St. Louis to Lafayette Amtrak Station via Chicago Union Station in around 8h 56m.

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