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How to get fromSt. Louis to Lake Cityby plane, bus, bus (Greyhound, Flixbus), car, or bus (Greyhound)

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There are 7 ways to get from St. Louis to Lake City by plane, bus, bus (Greyhound, Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Jacksonville, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Jacksonville (JAX)plane plane STL - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 4m
    $138–640

  2. Fly to Gainesville Regional Airport, bus

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Gainesville Regional Airport (GNV)plane plane STL - GNV
    2. Take the bus from Gainesville to Lake City Bus Stationbus bus
    9h 15m
    $126–590

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus FlixBus N2521
    2. Take the bus from Atlanta Bus Station to Lake City Bus Stationbus bus FlixBus 2451
    16h 55m
    $158–267

  4. Drive 836.8 mi

    1. Drive from St. Louis to Lake Citycar car 836.8 mi
    13h 49m
    $153–221

  5. Fly to Orlando, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Orlando (MCO)plane plane STL - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    9h 47m
    $212–426

  6. Fly to Valdosta, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Valdosta (VLD)plane plane STL - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    11h 6m
    $162–600

  7. Bus via Nashville

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Tallahasseebus bus
    4. Take the bus from Tallahassee to Lake City Bus Stationbus bus
    21h
    $227–334

St. Louis to Lake City by bus

Calendar7Weekly Buses
Duration16h 55mAverage Duration
Ticket$158Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Lake City.ExpandLaunch map view
  • Distance: 845.3 mi
  • Duration: 7h 4m

What companies run services between St. Louis, MO, USA and Lake City, FL, USA?

You can take a bus from St Louis Bus Station to Lake City Bus Station via Atlanta Bus Station in around 16h 55m.

Airlines
Bus operators

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