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How to get fromSt. Louis to Lake Cityby plane, bus, bus (Greyhound, Flixbus), or car

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There are 8 ways to get from St. Louis to Lake City by plane, bus, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Jacksonville, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Jacksonville (JAX)plane plane STL - JAX
    2. Take the bus from Jacksonville to Lake City Bus Stationbus bus
    7h 19m
    $114–572

  2. Fly to Gainesville Regional Airport, bus

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Gainesville Regional Airport (GNV)plane plane STL - GNV
    2. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    10h
    $98–488

  3. Bus

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Lake City Bus Stationbus bus
    20h
    $154–242

  4. Drive  836.8 mi

    1. Drive from St. Louis to Lake Citycar car 836.8 mi
    13h 48m
    $143–207

  5. Fly to Orlando, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Orlando (MCO)plane plane STL - MCO
    2. Take the bus from Orlando Bus Station to Lake City Bus Stationbus bus
    10h 6m
    $174–532

  6. Fly to Valdosta, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Valdosta (VLD)plane plane STL - VLD
    2. Take the bus from Valdosta to Gainesville Bus Stopbus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    10h 16m
    $120–508

  7. Bus via Atlanta

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Gainesvillebus bus
    3. Take the bus from Gainesville Bus Stop to Lake City Bus Stationbus bus
    21h 15m
    $150–243

  8. Bus via Atlanta #2

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Lake City Bus Stationbus bus
    22h 30m
    $154–258

St. Louis to Lake City by bus

Calendar7Weekly Buses
Duration20hAverage Duration
Ticket$154Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from St. Louis to Lake City.ExpandLaunch map view
  • Distance: 845.3 mi
  • Duration: 7h 19m

What companies run services between St. Louis, MO, USA and Lake City, FL, USA?

You can take a bus from St Louis Bus Station to Lake City Bus Station via Nashville Bus Station and Tallahassee in around 20h.

Airlines
Bus operators

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