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How to get fromSt. Louis to Lancasterby plane, bus (Greyhound), train (Amtrak), car, train, or subway

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There are 11 ways to get from St. Louis to Lancaster by plane, bus (Greyhound), train (Amtrak), car, train, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Harrisburg International Airport (MDT)plane plane STL - MDT
    9h 41m
    $108–566

  2. Bus (Greyhound)

    1. Take the bus from St Louis Bus Station to Harrisburg Bus Stationbus bus Greyhound US0421
    22h 32m
    $129–245

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    3. Take the train from Pittsburgh Amtrak Station to Elizabethtown Amtrak Stationtrain train
    24h 13m
    $327–685

  4. Drive 814.1 mi

    1. Drive from St. Louis to Lancastercar car 814.1 mi
    13h 58m
    $149–215

  5. Fly to Philadelphia International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Philadelphia International Airport (PHL)plane plane STL - PHL
    2. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    8h 50m
    $182–866

  6. Fly to Laguardia Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Laguardia Airport (LGA)plane plane STL - LGA
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Elizabethtown Amtrak Stationtrain train
    10h 39m
    $200–568

  7. Fly to Baltimore-Washington International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Baltimore-Washington International Airport (BWI)plane plane STL - BWI
    2. Take the train from BWI Thurgood Marshall to 30th Street Stationtrain train
    3. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    10h 17m
    $174–1,364

  8. Fly to Ronald Reagan Washington National Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Ronald Reagan Washington National Airport (DCA)plane plane STL - DCA
    2. Take the train from Washington Union Station to 30th Street Stationtrain train
    3. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    10h 22m
    $234–540

  9. Fly to Newark Liberty International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Newark Liberty International Airport (EWR)plane plane STL - EWR
    2. Take the train from Newark Liberty International Airport to 30th Street Stationtrain train
    3. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    10h 47m
    $424–918

  10. Fly to Pittsburgh International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Pittsburgh International Airport (PIT)plane plane STL - PIT
    2. Take the train from Pittsburgh Amtrak Station to Elizabethtown Amtrak Stationtrain train
    13h 29m
    $182–732

  11. Fly to Washington Dulles International Airport, subway, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Washington Dulles International Airport (IAD)plane plane STL - IAD
    2. Take the subway from Washington Dulles International Airport, Silver Line Center Platform to Farragut West, Blue/Orange/Silver Line Track 1 Platformsubway subway
    3. Take the train from Washington Union Station to 30th Street Stationtrain train
    4. Take the train from 30th Street Station to Elizabethtown Amtrak Stationtrain train
    11h 8m
    $254–1,158

St. Louis to Lancaster by bus and train (Greyhound)

Calendar21Weekly Services
Duration22h 32mAverage Duration
Ticket$129Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Lancaster.ExpandLaunch map view
  • Distance: 796.4 mi
  • Duration: 9h 41m

What companies run services between St. Louis, MO, USA and Lancaster, PA, USA?

Delta, American Airlines, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Harrisburg International Airport (MDT) hourly. Alternatively, Greyhound USA operates a bus from St Louis Bus Station to Harrisburg Bus Station 3 times a day. Tickets cost $120–240 and the journey takes 19h 20m.

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