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How to get fromSt. Louis to Lexingtonby bus, car, or plane

Find Transport to Lexington

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There are 5 ways to get from St. Louis to Lexington by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive

    best
    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville, IN to Louisville, KYbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    10h 22m
    $75–127

  2. Drive 337.8 mi

    cheapest
    1. Drive from St. Louis to Lexingtoncar car 337.8 mi
    5h 44m
    $62–90

  3. Fly to Louisville International Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    6h 20m
    $112–624

  4. Fly to Covington, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Covington (CVG)plane plane STL - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    6h 12m
    $128–724

  5. Fly to Blue Grass Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    7h 55m
    $174–1,004

Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) flights

Calendar112Weekly Planes
Duration4h 33mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Lexington.ExpandLaunch map view
  • Distance: 371.4 mi
  • Duration: 10h 22m

What companies run services between St. Louis, MO, USA and Lexington, KY, USA?

American Airlines, United Airlines, and Delta fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX) hourly.

Airlines
Bus operators

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