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How to get fromSt. Louis to Lexingtonby plane, bus (Amtrak, Flixbus, Greyhound), car, train, or bus (Greyhound, Flixbus)

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There are 6 ways to get from St. Louis to Lexington by plane, bus (Amtrak, Flixbus, Greyhound), car, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO)plane plane STL - GSO
    8h 7m
    $174–830

  2. Drive 699.3 mi

    cheapest
    1. Drive from St. Louis to Lexingtoncar car 699.3 mi
    12h 44m
    $128–185

  3. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    19h 53m
    $133–266

  4. Fly to Charlotte Douglas International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the train from Charlotte Amtrak Station to High Pointtrain train
    8h 11m
    $152–768

  5. Fly to Raleigh-Durham International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)plane plane STL - RDU
    2. Take the train from Durham Amtrak Station to High Pointtrain train
    8h 35m
    $582–1,062

  6. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus Greyhound US0670
    20h 28m
    $132–260

St. Louis to Lexington by bus

Calendar5Weekly Buses
Duration19h 53mAverage Duration
Ticket$133Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Lexington.ExpandLaunch map view
  • Distance: 648 mi
  • Duration: 8h 7m

What companies run services between St. Louis, MO, USA and Lexington, NC, USA?

Delta, American Airlines, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO) hourly. Alternatively, you can take a bus from St. Louis to Lexington via Carbondale Intermodal Station, Atlanta Bus Station, and Winston-Salem in around 19h 53m.

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