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How to get fromSt. Louis to Lisleby train (Amtrak), bus (Flixbus), car, plane, train, or bus

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There are 7 ways to get from St. Louis to Lisle by train (Amtrak), bus (Flixbus), car, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    6h 13m
    $159–243

  2. Drive  272.8 mi

    cheapest
    1. Drive from St. Louis to Lislecar car 272.8 mi
    4h 43m
    $50–72

  3. Bus

    1. Take the bus from St Louis Bus Station to Champaign Intermodal Trans Ctrbus bus FlixBus N2521 / ...
    2. Take the bus from Illinois Terminal to Oakbrook Mallbus bus Champaign to Chicago ends at Woodfield NB / ...
    8h 38m
    $76–107

  4. Fly Lambert–St. Louis International Airport to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago Union Station to Lisletrain train
    4h 47m
    $58–384

  5. Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the train from Chicago Union Station to Lisletrain train
    5h 13m
    $328–714

  6. Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane plane SPI - ORD
    6h 26m
    $102–338

  7. Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    6h 59m
    $131–283

St. Louis to Lisle by train (Amtrak)

Calendar38Weekly Trains
Duration6h 13mAverage Duration
Ticket$159Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Lisle.ExpandLaunch map view
  • Distance: 304.9 mi
  • Duration: 6h 13m

What companies run services between St. Louis, MO, USA and Lisle, IL, USA?

Amtrak operates a train from St. Louis to Chicago Union Station 5 times a day. Tickets cost $150–240 and the journey takes 4h 55m. Alternatively, you can take a bus from St Louis Bus Station to Ogden Ave & Main St via Champaign Intermodal Trans Ctr, Illinois Terminal, Oak Brook Center / Macy's, and Yorktown Center in around 8h 38m.

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