There are 4 ways to get from St. Louis to Louisville by bus (Greyhound), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from St Louis Bus Station to Evansville Bus Stationbus Greyhound US0185 / ...
- Take the bus from Evansville, IN to Louisville, KYbus Evansville
6h 40m$62–105Drive 259.1 mi
cheapest- Drive from St. Louis to Louisvillecar 259.1 mi
4h 16m$48–69Fly to Louisville International Airport
- Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane STL - SDF
6h 2m$104–606Fly to Blue Grass Airport, drive
- Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane STL - LEX
- Drive from Lexington-Airport-LEX to Louisvillecar
6h 50m$196–1,022
St. Louis to Louisville by bus
Questions & Answers
The cheapest way to get from St. Louis to Louisville is to drive which costs $45 - $70 and takes 4h 16m.
The fastest way to get from St. Louis to Louisville is to drive which takes 4h 16m and costs $45 - $70.
No, there is no direct bus from St. Louis station to Louisville. However, there are services departing from St Louis Bus Station and arriving at Louisville, KY via Evansville, IN. The journey, including transfers, takes approximately 6h 40m.
The distance between St. Louis and Louisville is 286 miles. The road distance is 260.6 miles.
The best way to get from St. Louis to Louisville without a car is to bus which takes 6h 40m and costs $60 - $110.
It takes approximately 6h 40m to get from St. Louis to Louisville, including transfers.
St. Louis to Louisville bus services, operated by Greyhound USA, depart from St Louis Bus Station.
The best way to get from St. Louis to Louisville is to bus which takes 6h 40m and costs $60 - $110. Alternatively, you can fly, which costs $100 - $650 and takes 6h 2m.
St. Louis to Louisville bus services, operated by Greyhound USA, arrive at Evansville Bus Station.
Louisville is 1h ahead of St. Louis. It is currently 9:47 PM in St. Louis and 10:47 PM in Louisville.
What companies run services between St. Louis, MO, USA and Louisville, KY, USA?
You can take a bus from St Louis Bus Station to Louisville, KY via Evansville, IN in around 6h 40m. Alternatively, Southwest Airlines, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) hourly.
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Atlanta
- Ave. Duration
- 5h 1m
- When
- Every day
- Estimated price
- $150–750
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Detroit
- Ave. Duration
- 5h 39m
- When
- Every day
- Estimated price
- $140–750
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 4h 47m
- When
- Every day
- Estimated price
- $220–1,100
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Detroit
- Ave. Duration
- 6h 5m
- When
- Every day
- Estimated price
- $210–1,100
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Minneapolis
- Ave. Duration
- 6h 38m
- When
- Saturday
- Estimated price
- $280–1,300
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 3h 57m
- When
- Every day
- Estimated price
- $120–650
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Charlotte
- Ave. Duration
- 4h 38m
- When
- Every day
- Estimated price
- $160–800
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $180–1,000
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Charlotte
- Ave. Duration
- 4h 53m
- When
- Every day
- Estimated price
- $230–1,200
- Website
- united.com
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $120–650
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $180–1,000
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Chicago Midway
- Ave. Duration
- 3h 58m
- When
- Every day
- Estimated price
- $110–650
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Nashville
- Ave. Duration
- 4h 20m
- When
- Monday to Wednesday
- Estimated price
- $100–600
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from St Louis Bus Station to Evansville Bus Station
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- $26–50
- Website
- https://www.greyhound.com/
- Phone
- +1 502-368-5644 x 135
- Website
- ridewithmiller.com
Bus from Evansville, IN to Louisville, KY
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $35–55
- Website
- https://ridewithmiller.com
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More Questions & Answers
Yes, the driving distance between St. Louis to Louisville is 261 miles. It takes approximately 4h 16m to drive from St. Louis to Louisville.
Book your St. Louis to Louisville bus tickets online with Omio.
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