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How to get fromSt. Louis to Louisvilleby bus (Greyhound), car, or plane

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There are 4 ways to get from St. Louis to Louisville by bus (Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus Greyhound US0185 / ...
    2. Take the bus from Evansville, IN to Louisville, KYbus bus Evansville
    6h 40m
    $59–174

  2. Drive 259.1 mi

    cheapest
    1. Drive from St. Louis to Louisvillecar car 259.1 mi
    4h 16m
    $48–69

  3. Fly to Louisville International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    6h 2m
    $104–656

  4. Fly to Blue Grass Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 26m
    $96–472

St. Louis to Louisville by bus

Calendar7Weekly Buses
Duration6h 40mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Louisville.ExpandLaunch map view
  • Distance: 283.9 mi
  • Duration: 6h 40m

What companies run services between St. Louis, MO, USA and Louisville, KY, USA?

You can take a bus from St Louis Bus Station to Louisville, KY via Evansville, IN in around 6h 40m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) hourly.

Airlines
Bus operators

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Need to know: Greyhound

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