There are 4 ways to get from St. Louis to Louisville, KY by bus (Greyhound), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from St Louis Bus Station to Evansville Bus Stationbus Greyhound US0185 / ...
- Take the bus from Evansville, IN to Louisville, KYbus Evansville
6h 40m$66–175Drive 258.8 mi
cheapest- Drive from St. Louis to Louisville, KYcar 258.8 mi
4h 16m$46–67Fly to Louisville International Airport
- Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane STL - SDF
6h 24m$124–806Fly to Blue Grass Airport, drive
- Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane STL - LEX
- Drive from Lexington-Airport-LEX to Louisville, KYcar
6h 30m$90–462
St. Louis to Louisville, KY by bus
Comparing Your Travel Options
The cheapest way to get from St. Louis to Louisville, KY is to drive which costs $45 - $70 and takes 4h 16m.
The fastest way to get from St. Louis to Louisville, KY is to drive which takes 4h 16m and costs $45 - $70.
No, there is no direct bus from St. Louis station to Louisville, KY. However, there are services departing from St Louis Bus Station and arriving at Louisville, KY via Evansville, IN. The journey, including transfers, takes approximately 6h 40m.
The distance between St. Louis and Louisville, KY is 286 miles. The road distance is 260.4 miles.
The best way to get from St. Louis to Louisville, KY without a car is to bus which takes 6h 40m and costs $65 - $180.
It takes approximately 6h 40m to get from St. Louis to Louisville, KY, including transfers.
St. Louis to Louisville, KY bus services, operated by Greyhound USA, depart from St Louis Bus Station.
The best way to get from St. Louis to Louisville, KY is to bus which takes 6h 40m and costs $65 - $180. Alternatively, you can fly, which costs $120 - $850 and takes 6h 24m.
St. Louis to Louisville, KY bus services, operated by Greyhound USA, arrive at Evansville Bus Station.
Louisville, KY is 1h ahead of St. Louis. It is currently 11:32 PM in St. Louis and 12:32 AM in Louisville, KY.
What companies run services between St. Louis, MO, USA and Louisville, KY, USA?
You can take a bus from St Louis Bus Station to Louisville, KY via Evansville, IN in around 6h 40m. Alternatively, Southwest Airlines, Delta, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) hourly.
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $140–850
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Charlotte
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $190–1,000
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 4h 46m
- When
- Every day
- Estimated price
- $75–440
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Charlotte
- Ave. Duration
- 5h 21m
- When
- Every day
- Estimated price
- $95–500
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 9m
- When
- Every day
- Estimated price
- $130–600
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Atlanta
- Ave. Duration
- 3h 54m
- When
- Every day
- Estimated price
- $170–950
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Detroit
- Ave. Duration
- 5h 47m
- When
- Every day
- Estimated price
- $170–900
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Atlanta
- Ave. Duration
- 3h 56m
- When
- Every day
- Estimated price
- $90–490
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Detroit
- Ave. Duration
- 5h 47m
- When
- Every day
- Estimated price
- $85–470
- Website
- united.com
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Chicago O'Hare
- Ave. Duration
- 4h 25m
- When
- Every day
- Estimated price
- $140–850
Flights from Lambert–St. Louis International Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $75–440
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Nashville
- Ave. Duration
- 4h 3m
- When
- Tuesday, Wednesday, and Saturday
- Estimated price
- $120–800
Flights from Lambert–St. Louis International Airport to Louisville International Airport via Chicago Midway
- Ave. Duration
- 3h 48m
- When
- Tuesday, Wednesday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $140–850
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from St Louis Bus Station to Evansville Bus Station
- Ave. Duration
- 3h 25m
- Frequency
- Twice daily
- Estimated price
- $30–45
- Website
- Greyhound
- Phone
- +1 502-368-5644 x 135
- Website
- Miller Transportation
Bus from Evansville, IN to Louisville, KY
- Ave. Duration
- 2h 15m
- Frequency
- Once daily
- Estimated price
- $35–130
- Website
- Miller Transportation
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Booking & Getting There
Yes, the driving distance between St. Louis to Louisville, KY is 260 miles. It takes approximately 4h 16m to drive from St. Louis to Louisville, KY.
There are 614+ hotels available in Louisville, KY.