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How to get fromSt. Louis to Louisville, KYby bus (Greyhound), car, plane, or bus

Find Transport to Louisville, KY

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There are 4 ways to get from St. Louis to Louisville, KY by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus Greyhound US0185 / ...
    2. Take the bus from Evansville, IN to Louisville, KYbus bus Evansville / ...
    6h 40m
    $61–105

  2. Drive 258.8 mi

    cheapest
    1. Drive from St. Louis to Louisville, KYcar car 258.8 mi
    4h 16m
    $48–69

  3. Fly to Louisville International Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    6h 34m
    $104–606

  4. Fly to Nashville, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    2. Take the bus from Nashville Bus Station to Louisville Bus Stationbus bus
    6h 53m
    $112–530

St. Louis to Louisville, KY by bus

Calendar14Weekly Buses
Duration6h 40mAverage Duration
Ticket$61Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Louisville, KY.ExpandLaunch map view
  • Distance: 283.9 mi
  • Duration: 6h 40m

What companies run services between St. Louis, MO, USA and Louisville, KY, USA?

You can take a bus from St Louis Bus Station to Louisville, KY via Evansville, IN in around 6h 40m. Alternatively, Southwest Airlines, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) hourly.

Airlines
Bus operators

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Need to know: Greyhound

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