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How to get fromSt. Louis to Louisvilleby plane, bus, bus (Greyhound), train, or car

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There are 8 ways to get from St. Louis to Louisville by plane, bus, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Cleveland-Hopkins International Airport, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Cleveland-Hopkins International Airport (CLE)plane plane STL - CLE
    2. Take the bus from Cleveland Ohio Greyhound Station to Canton Ohio Sarta Transit Stationbus bus
    7h 40m
    $506–970

  2. Fly Lambert–St. Louis International Airport to Akron

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Akron (CAK)plane plane STL - CAK
    8h 30m
    $70–364

  3. Bus

    1. Take the bus from St Louis Bus Station to Cambridge, OHbus bus Greyhound US0421
    2. Take the bus from Cambridge to Cantonbus bus Route C NB
    16h 8m
    $83–183

  4. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Cleveland Amtraktrain train
    3. Take the bus from Cleveland Ohio Greyhound Station to Canton Ohio Sarta Transit Stationbus bus 380
    16h 12m
    $192–461

  5. Drive 544.6 mi

    1. Drive from St. Louis to Louisvillecar car 544.6 mi
    9h 28m
    $100–144

  6. Fly Lambert–St. Louis International Airport to John Glenn Columbus International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to John Glenn Columbus International Airport (CMH)plane plane STL - CMH
    2. Take the bus from John Glenn Columbus Intnl Airport (CMH) to Canton Ohio Sarta Transit Stationbus bus
    9h 4m
    $850–1,064

  7. Train to Abraham Lincoln Capital Airport, fly to Akron

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Akron (CAK)plane plane SPI - CAK
    10h 47m
    $89–349

  8. Fly Lambert–St. Louis International Airport to Pittsburgh International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Pittsburgh International Airport (PIT)plane plane STL - PIT
    2. Take the bus from Pittsburgh Intermodal Station to Robert K Pfaff Transit Center - Akronbus bus
    3. Take the bus from Robert K Pfaff Transit Center - Akron to Cornerstone Transit Centerbus bus
    11h 6m
    $114–624

St. Louis to Louisville by bus

Calendar7Weekly Buses
Duration16h 8mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Louisville.ExpandLaunch map view
  • Distance: 584.1 mi
  • Duration: 7h 40m

What companies run services between St. Louis, MO, USA and Louisville, Stark County, OH, USA?

You can take a bus from St Louis Bus Station to E Main St And N Chapel St via Cambridge, OH, Cambridge, and Cornerstone Transit Center in around 16h 8m. Alternatively, United Airlines and American Airlines fly from Lambert–St. Louis International Airport (STL) to Akron (CAK) every 3 hours.

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