What is the cheapest way to get from St. Louis to Manchester?

The cheapest way to get from St. Louis to Manchester is to drive which costs $75 - $110 and takes 7h 33m.

What is the fastest way to get from St. Louis to Manchester?

The fastest way to get from St. Louis to Manchester is to fly and drive which takes 7h 23m and costs $200 - $1,100.

Is there a direct bus between St. Louis and Manchester?

No, there is no direct bus from St. Louis station to Manchester. However, there are services departing from St Louis Bus Station and arriving at London via Indianapolis, IN and Cincinnati Bus Station. The journey, including transfers, takes approximately 13h 19m.

How far is it from St. Louis to Manchester?

The distance between St. Louis and Manchester is 552 miles. The road distance is 419.5 miles.

How do I travel from St. Louis to Manchester without a car?

The best way to get from St. Louis to Manchester without a car is to bus via Indianapolis which takes 13h 19m and costs $130 - $250.

How long does it take to get from St. Louis to Manchester?

It takes approximately 7h 57m to get from St. Louis to Manchester, including transfers.

Where do I catch the St. Louis to Manchester bus from?

St. Louis to Manchester bus services, operated by Greyhound USA, depart from St Louis Bus Station.

Where does the St. Louis to Manchester bus arrive?

St. Louis to Manchester bus services, operated by Greyhound USA, arrive at Indianapolis Union Station.

What is the time difference between St. Louis and Manchester?

Manchester is 1h ahead of St. Louis. It is currently 4:48 PM in St. Louis and 5:48 PM in Manchester.

Can I drive from St. Louis to Manchester?

Yes, the driving distance between St. Louis to Manchester is 420 miles. It takes approximately 7h 33m to drive from St. Louis to Manchester.

Where can I stay near Manchester?

There are one+ hotels available in Manchester.

St. Louis to Manchester - 6 ways to travel via plane, car, and bus

How to get fromSt. Louis to Manchester

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There are 6 ways to get from St. Louis to Manchester by plane, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly to Mcghee Tyson Airport, drive
best
1. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane STL - TYS
2. Drive from Mcghee Tyson Airport (TYS) to Manchestercar
7h 57m
$146–788
Drive 417.1 mi
cheapest
1. Drive from St. Louis to Manchestercar 417.1 mi
7h 33m
$77–110
Bus via Indianapolis
1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus
2. Take the bus from Indianapolis, IN to Greyhound Station Cincinnatibus
3. Take the bus from Cincinnati Bus Station to Londonbus
13h 19m
$136–250
Fly to Blue Grass Airport, drive
1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane STL - LEX
2. Drive from Lexington-Airport-LEX to Manchestercar
7h 23m
$200–1,030
Fly to Tri-Cities Regional Tn/Va Airport, drive
1. Fly from Lambert–St. Louis International Airport (STL) to Tri-Cities Regional Tn/Va Airport (TRI)plane STL - TRI
2. Drive from Tri-Cities-Regional-Airport-TRI to Manchestercar
8h 25m
$146–688
Bus (Greyhound)
1. Take the bus from St Louis Bus Station to Dayton Trotwood Bus Stationbus Greyhound US0421
2. Take the bus from Dayton Trotwood Bus Station to Londonbus Greyhound US0110
13h 44m
$144–246

Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS) flights

113Weekly Planes

5h 2mAverage Duration

$128Cheapest Price

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Questions & Answers

Map of how to get from St. Louis to Manchester.

Launch map view

Distance: 548.7 mi
Duration: 7h 57m

What companies run services between St. Louis, MO, USA and Manchester, KY, USA?

You can take a bus from St Louis Bus Station to Manchester via Indianapolis, IN, Greyhound Station Cincinnati, Cincinnati Bus Station, and London in around 13h 19m.

Airlines

Bus operators

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How to get fromSt. Louis to Manchesterby plane, car, or bus (Greyhound)

There are 6 ways to get from St. Louis to Manchester by plane, car, or bus (Greyhound)

Fly to Mcghee Tyson Airport, drive

Drive 417.1 mi

Bus via Indianapolis

Fly to Blue Grass Airport, drive

Fly to Tri-Cities Regional Tn/Va Airport, drive

Bus (Greyhound)