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How to get fromSt. Louis to Manchesterby bus (Greyhound, Flixbus), car, plane, bus, or bus (Amtrak, Flixbus, Greyhound)

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There are 7 ways to get from St. Louis to Manchester by bus (Greyhound, Flixbus), car, plane, bus, or bus (Amtrak, Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus Greyhound US0186 / ...
    2. Take the bus from Nashville Bus Station to Manchesterbus bus Greyhound US0105 / ...
    9h 25m
    $58–111

  2. Bus via Carbondale

    cheapest
    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Manchesterbus bus
    9h 45m
    $55–125

  3. Drive 368.6 mi

    1. Drive from St. Louis to Manchestercar car 368.6 mi
    6h 3m
    $68–98

  4. Fly to Nashville, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Nashville (BNA)plane plane STL - BNA
    2. Take the bus from Nashville Bus Station to Manchesterbus bus
    6h 9m
    $94–624

  5. Fly to Huntsville International Airport-Carl T Jones Field, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Huntsville International Airport-Carl T Jones Field (HSV)plane plane STL - HSV
    2. Drive from Huntsville International Airport-Carl T Jones Field (HSV) to Manchestercar car
    7h
    $126–674

  6. Fly to Chattanooga Metropolitan Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Chattanooga Metropolitan Airport (CHA)plane plane STL - CHA
    2. Take the bus from Groome Transportation Chattanooga to Circle K - Manchesterbus bus
    7h 32m
    $228–984

  7. Fly to Hartsfield-Jackson Atlanta International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Hartsfield-Jackson Atlanta International Airport (ATL)plane plane STL - ATL
    2. Take the bus from Atlanta Bus Station to Manchesterbus bus
    7h 59m
    $134–660

St. Louis to Manchester by bus

Calendar19Weekly Buses
Duration9h 25mAverage Duration
Ticket$58Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Manchester.ExpandLaunch map view
  • Distance: 379.4 mi
  • Duration: 9h 25m

What companies run services between St. Louis, MO, USA and Manchester, TN, USA?

You can take a bus from St Louis Bus Station to Manchester via Nashville Bus Station in around 9h 25m.

Airlines
Bus operators

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