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How to get fromSt. Louis to Mayo Clinicby plane, train, bus, car, or bus (Flixbus, Greyhound)

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There are 7 ways to get from St. Louis to Mayo Clinic by plane, train, bus, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Rochester

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (RST)plane plane STL - RST
    7h 7m
    $74–462

  2. Train, bus via Madison

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    14h 41m
    $143–291

  3. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    15h 59m
    $191–441

  4. Drive  449.1 mi

    1. Drive from St. Louis to Mayo Cliniccar car 449.1 mi
    8h 10m
    $82–119

  5. Fly Lambert–St. Louis International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 54m
    $434–1,004

  6. Train to Abraham Lincoln Capital Airport, fly to Rochester

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Rochester (RST)plane plane SPI - RST
    8h 55m
    $92–461

  7. Bus

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    15h 33m
    $131–193

St. Louis to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration14h 41mAverage Duration
Ticket$143Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Mayo Clinic.ExpandLaunch map view
  • Distance: 397 mi
  • Duration: 7h 7m

What companies run services between St. Louis, MO, USA and Mayo Clinic, MN, USA?

United Airlines, Delta, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Rochester (RST) every 3 hours. Alternatively, you can take a bus from St Louis Bus Station to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 15h 33m.

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