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How to get fromSt. Louis to Mechanicsburgby plane, bus (Greyhound), train (Amtrak), car, or train

Find Transport to Mechanicsburg

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There are 5 ways to get from St. Louis to Mechanicsburg by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Harrisburg International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Harrisburg International Airport (MDT)plane plane STL - MDT
    7h 24m
    $104–556

  2. Bus

    1. Take the bus from St Louis Bus Station to Harrisburg Bus Stationbus bus Greyhound US0421
    20h 24m
    $129–243

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    3. Take the train from Pittsburgh Amtrak Station to Harrisburgtrain train
    22h 49m
    $323–666

  4. Drive 771.2 mi

    1. Drive from St. Louis to Mechanicsburgcar car 771.2 mi
    13h 17m
    $141–204

  5. Fly to Philadelphia International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Philadelphia International Airport (PHL)plane plane STL - PHL
    2. Take the train from 30th Street Station to Harrisburgtrain train
    8h 16m
    $196–1,178

St. Louis to Mechanicsburg by bus and foot

Calendar42Weekly Services
Duration20h 24mAverage Duration
Ticket$129Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Mechanicsburg.ExpandLaunch map view
  • Distance: 765.1 mi
  • Duration: 7h 24m

What companies run services between St. Louis, MO, USA and Mechanicsburg, Cumberland County, PA, USA?

Delta, American Airlines, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Harrisburg International Airport (MDT) hourly. Alternatively, Greyhound-us operates a bus from St Louis Bus Station to Harrisburg Bus Station 3 times a day, and the journey takes 19h 20m. Greyhound USA also services this route 3 times a day.

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