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How to get fromSt. Louis to Middletonby train, bus, bus (Flixbus), car, or plane

Find Transport to Middleton

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There are 7 ways to get from St. Louis to Middleton by train, bus, bus (Flixbus), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    10h 18m
    $97–218

  2. Drive  363.2 mi

    cheapest
    1. Drive from St. Louis to Middletoncar car 363.2 mi
    6h 9m
    $67–96

  3. Bus

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    11h 54m
    $75–129

  4. Fly to Dane County Regional Airport-Truax Field

    1. Fly from Lambert–St. Louis International Airport (STL) to Dane County Regional Airport-Truax Field (MSN)plane plane STL - MSN
    7h 24m
    $102–656

  5. Train, bus via Milwaukee

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee, WI - Amtrak to Madison, WI-Lake St.bus bus
    11h 23m
    $112–253

  6. Fly to General Mitchell International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane plane STL - MKE
    2. Take the bus from Mitchell Airport to Madison, WI-Lake St.bus bus
    7h 5m
    $504–890

  7. Fly to Chicago O'Hare International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus
    8h 23m
    $348–810

St. Louis to Middleton by train and bus

Calendar38Weekly Services
Duration10h 18mAverage Duration
Ticket$97Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Middleton.ExpandLaunch map view
  • Distance: 442.2 mi
  • Duration: 10h 18m

What companies run services between St. Louis, MO, USA and Middleton, WI, USA?

You can take a bus from St Louis Bus Station to University at Park via Chicago Bus Station, W Jackson Blvd, after S Clinton St, 250 N. Lake St - Madison UW Campus, and University at East Campus in around 11h 54m. Alternatively, United Airlines, Delta, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Dane County Regional Airport-Truax Field (MSN) hourly.

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