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How to get fromSt. Louis to Midlothianby train (Amtrak), bus (Flixbus), car, plane, train, or bus

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There are 8 ways to get from St. Louis to Midlothian by train (Amtrak), bus (Flixbus), car, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from St. Louis to Joliet Gateway Centertrain train Lincoln Service / ...
    5h 10m
    $84–166

  2. Drive 277.2 mi

    cheapest
    1. Drive from St. Louis to Midlothiancar car 277.2 mi
    4h 48m
    $51–74

  3. Bus

    1. Take the bus from St Louis Bus Station to Chicagobus bus FlixBus N2521
    7h 31m
    $54–88

  4. Fly Lambert–St. Louis International Airport to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from LaSalle Street to Midlothiantrain train
    4h 25m
    $64–374

  5. Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the train from LaSalle Street to Midlothiantrain train
    4h 49m
    $278–714

  6. Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane plane SPI - ORD
    5h 59m
    $80–310

  7. Fly Lambert–St. Louis International Airport to General Mitchell International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane plane STL - MKE
    2. Take the bus from Mitchell Airport to O'Hare International Airport - Terminal 2 Departuresbus bus
    6h 31m
    $524–902

  8. Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    6h 50m
    $137–317

St. Louis to Midlothian by train (Amtrak)

Calendar38Weekly Trains
Duration5h 10mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Midlothian.ExpandLaunch map view
  • Distance: 265.7 mi
  • Duration: 5h 10m

What companies run services between St. Louis, MO, USA and Midlothian, IL, USA?

Amtrak operates a train from St. Louis to Joliet Gateway Center 5 times a day. Tickets cost $75–160 and the journey takes 3h 54m. Alternatively, FlixBus-us operates a bus from St Louis Bus Station to Chicago twice daily, and the journey takes 5h 50m. Flixbus USA also services this route 5 times a week.

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