Rome2Rio

How to get fromSt. Louis to Missionby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Amtrak, Flixbus)

Find Transport to Mission

See all options

There are 7 ways to get from St. Louis to Mission by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcallen Miller International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Mcallen Miller International Airport (MFE)plane plane STL - MFE
    6h 14m
    $182–828

  2. Fly to Rio Grande Valley International Airport, bus

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Rio Grande Valley International Airport (HRL)plane plane STL - HRL
    2. Take the bus from Harlingen Bus Station to Palmviewbus bus
    9h 11m
    $130–618

  3. Bus via Oklahoma City

    1. Take the bus from St Louis Bus Station to Oklahoma City Bus Stationbus bus
    2. Take the bus from Oklahoma City Bus Station to Downtown Dallas / Deep Ellumbus bus
    3. Take the bus from Dallas to McAllen Central Stationbus bus
    26h 26m
    $202–331

  4. Train, bus via Dallas

    1. Take the train from St. Louis to Dallastrain train Texas Eagle
    2. Take the bus from Dallas to McAllen Central Stationbus bus Dallas
    27h 7m
    $324–590

  5. Drive 1,133.6 mi

    1. Drive from St. Louis to Missioncar car 1,133.6 mi
    18h 50m
    $207–299

  6. Bus

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Marathon Gas Station - Marion to Laredobus bus
    3. Take the bus from Laredo - OMEX to McAllen Central Stationbus bus
    31h 17m
    $206–393

  7. Train, bus

    1. Take the train from St. Louis to San Marcos Amtraktrain train Texas Eagle
    2. Take the bus from San Marcos to McAllen Central Stationbus bus FlixBus US1164
    34h 49m
    $372–741

Lambert–St. Louis International Airport (STL) to Mcallen Miller International Airport (MFE) flights

Calendar47Weekly Planes
Duration5h 27mAverage Duration
Ticket$167Cheapest Price
See schedules

Questions & Answers

Map of how to get from St. Louis to Mission.ExpandLaunch map view
  • Distance: 1,002.1 mi
  • Duration: 6h 14m

What companies run services between St. Louis, MO, USA and Mission, TX, USA?

American Airlines and United Airlines fly from Lambert–St. Louis International Airport (STL) to Mcallen Miller International Airport (MFE) every 4 hours. Alternatively, you can take a bus from St Louis Bus Station to First / Conway via Oklahoma City Bus Station, Downtown Dallas / Deep Ellum, Gaston @ Good Latimer - S- Ns, Jefferson @ Marsalis - W - Ns, Dallas, and McAllen Central Station in around 26h 26m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers