There are 2 ways to get from St. Louis to Murphysboro by bus (Flixbus, Amtrak) or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Comparing Your Travel Options
The cheapest way to get from St. Louis to Murphysboro is to drive which costs $16 - $24 and takes 2h 9m.
The fastest way to get from St. Louis to Murphysboro is to bus which takes 2h and costs $30 - $50.
No, there is no direct bus from St. Louis station to Murphysboro station. However, there are services departing from St Louis Bus Station and arriving at Carbondale Intermodal Station via . The journey, including transfers, takes approximately 2h.
The distance between St. Louis and Murphysboro is 104 miles. The road distance is 88.9 miles.
The best way to get from St. Louis to Murphysboro without a car is to bus which takes 2h and costs $30 - $50.
It takes approximately 2h to get from St. Louis to Murphysboro, including transfers.
St. Louis to Murphysboro bus services, operated by Flixbus USA, depart from St Louis Bus Station.
St. Louis to Murphysboro bus services, operated by Flixbus USA, arrive at Carbondale Intermodal Station.
Yes, the driving distance between St. Louis to Murphysboro is 89 miles. It takes approximately 2h 9m to drive from St. Louis to Murphysboro.
Book your St. Louis to Murphysboro bus tickets online with Omio.
What companies run services between St. Louis, MO, USA and Murphysboro, IL, USA?
Flixbus USA operates a bus from St Louis Bus Station to Carbondale Intermodal Station 5 times a week. Tickets cost $15–23 and the journey takes 1h 50m. Amtrak also services this route once daily.
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from St Louis Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- $15–23
- Schedules at
- Flixbus USA
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Bus from St Louis Bus Station to Carbondale Intermodal Station
- Ave. Duration
- 2h
- Frequency
- Once daily
- Website
- Amtrak
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Booking & Getting There
There are 35+ hotels available in Murphysboro.