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How to get fromSt. Louis to New Castleby plane, bus, bus (Greyhound), train, or car

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There are 6 ways to get from St. Louis to New Castle by plane, bus, bus (Greyhound), train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Pittsburgh International Airport, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Pittsburgh International Airport (PIT)plane plane STL - PIT
    2. Take the bus from East Busway At Penn Station D to Transit Center, PAbus bus
    6h 57m
    $100–564

  2. Bus

    cheapest
    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus Greyhound US0421
    2. Take the bus from East Busway At Penn Station D to Transit Center, PAbus bus Pittsburgh Outbound
    16h 10m
    $95–185

  3. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Pittsburgh Amtrak Stationtrain train
    3. Take the bus from East Busway At Penn Station D to Transit Center, PAbus bus
    17h 35m
    $243–517

  4. Drive 600.4 mi

    1. Drive from St. Louis to New Castlecar car 600.4 mi
    10h 23m
    $110–159

  5. Fly to Akron, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Akron (CAK)plane plane STL - CAK
    2. Take the bus from Robert K Pfaff Transit Center - Akron to Youngstown Bus Stopbus bus
    9h 36m
    $124–436

  6. Fly to Cleveland-Hopkins International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Cleveland-Hopkins International Airport (CLE)plane plane STL - CLE
    2. Take the bus from Cleveland Bus Station to Pittsburgh Intermodal Stationbus bus
    3. Take the bus from East Busway At Penn Station D to Transit Center, PAbus bus
    8h 40m
    $518–958

Lambert–St. Louis International Airport (STL) to Pittsburgh International Airport (PIT) flights

Calendar50Weekly Planes
Duration3h 28mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to New Castle.ExpandLaunch map view
  • Distance: 643.6 mi
  • Duration: 6h 57m

What companies run services between St. Louis, MO, USA and New Castle, Lawrence County, PA, USA?

You can take a bus from St Louis Bus Station to Transit Center, PA via Pittsburgh Intermodal Station and East Busway At Penn Station D in around 16h 10m.

Airlines
Train operators
Bus operators

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