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How to get fromSt. Louis to Orangeburgby plane, taxi, bus (Amtrak, Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from St. Louis to Orangeburg by plane, taxi, bus (Amtrak, Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Columbia, taxi

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Columbia (CAE)plane plane STL - CAE
    2. Take the taxi from Columbia-Airport-CAE to Orangeburgtaxi taxi
    5h 36m
    $202–612

  2. Fly to Augusta Regional Airport At Bush Field, drive

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Augusta Regional Airport At Bush Field (AGS)plane plane STL - AGS
    2. Drive from Augusta Regional Airport At Bush Field (AGS) to Orangeburgcar car
    6h 38m
    $96–474

  3. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Camdenbus bus
    4. Take the bus from Camden to Orangeburgbus bus
    20h 28m
    $136–245

  4. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Denmark Amtrak Stationtrain train Floridian
    36h 17m
    $489–1,042

  5. Drive  773.9 mi

    1. Drive from St. Louis to Orangeburgcar car 773.9 mi
    13h 3m
    $142–204

  6. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Camdenbus bus
    3. Take the bus from Camden to Orangeburgbus bus
    21h 3m
    $141–236

Lambert–St. Louis International Airport (STL) to Columbia (CAE) flights

Calendar150Weekly Planes
Duration4h 58mAverage Duration
Ticket$84Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Orangeburg.ExpandLaunch map view
  • Distance: 664.6 mi
  • Duration: 5h 36m

What companies run services between St. Louis, MO, USA and Orangeburg, SC, USA?

You can take a bus from St. Louis to Orangeburg via Carbondale Intermodal Station, Atlanta Bus Station, Camden, and Orangeburg in around 20h 28m. Alternatively, you can take a train from St. Louis to Orangeburg via Chicago Union Station and Denmark Amtrak Station in around 36h 17m.

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