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How to get fromSt. Louis to Orangeburgby plane, car, bus (Amtrak, Flixbus, Greyhound), train (Amtrak), taxi, train, bus, or bus (Greyhound, Flixbus)

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There are 10 ways to get from St. Louis to Orangeburg by plane, car, bus (Amtrak, Flixbus, Greyhound), train (Amtrak), taxi, train, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charleston International Airport, drive

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Charleston International Airport (CHS)plane plane STL - CHS
    2. Drive from Charleston-Airport-CHS to Orangeburgcar car
    4h 38m
    $114–572

  2. Fly to Augusta Regional Airport At Bush Field, drive

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Augusta Regional Airport At Bush Field (AGS)plane plane STL - AGS
    2. Drive from Augusta Regional Airport At Bush Field (AGS) to Orangeburgcar car
    6h 43m
    $92–464

  3. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Camdenbus bus
    4. Take the bus from Camden to Orangeburgbus bus
    20h 28m
    $148–230

  4. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Denmark Amtrak Stationtrain train Floridian
    36h 17m
    $920–1,518

  5. Drive  773.9 mi

    1. Drive from St. Louis to Orangeburgcar car 773.9 mi
    13h 3m
    $142–204

  6. Fly to Columbia, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Columbia (CAE)plane plane STL - CAE
    2. Take the taxi from Columbia-Airport-CAE to Orangeburgtaxi taxi
    5h 39m
    $202–592

  7. Fly to Savannah, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Savannah (SAV)plane plane STL - SAV
    2. Take the train from Savannah Station to Denmark Amtrak Stationtrain train
    6h 30m
    $282–958

  8. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    7h 38m
    $146–708

  9. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Orangeburgbus bus
    20h 38m
    $152–261

  10. Bus #2

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Camdenbus bus
    3. Take the bus from Camden to Orangeburgbus bus
    21h 3m
    $151–244

Lambert–St. Louis International Airport (STL) to Charleston International Airport (CHS) flights

Calendar52Weekly Planes
Duration3h 46mAverage Duration
Ticket$101Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Orangeburg.ExpandLaunch map view
  • Distance: 789.1 mi
  • Duration: 4h 38m

What companies run services between St. Louis, MO, USA and Orangeburg, SC, USA?

You can take a bus from St. Louis to Orangeburg via Carbondale Intermodal Station, Atlanta Bus Station, Camden, and Orangeburg in around 20h 28m. Alternatively, you can take a train from St. Louis to Orangeburg via Chicago Union Station and Denmark Amtrak Station in around 36h 17m.

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