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How to get fromSt. Louis to Palatineby train (Amtrak), bus (Flixbus), car, plane, train, or bus

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There are 9 ways to get from St. Louis to Palatine by train (Amtrak), bus (Flixbus), car, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago OTC to Palatinetrain train Up-Nw
    6h 25m
    $99–194

  2. Drive 297.2 mi

    cheapest
    1. Drive from St. Louis to Palatinecar car 297.2 mi
    5h 8m
    $55–79

  3. Bus

    1. Take the bus from St Louis Bus Station to Champaign Intermodal Trans Ctrbus bus FlixBus 2510 / ...
    2. Take the bus from Illinois Terminal to Woodfield Mallbus bus Champaign to Chicago via shopping areas NB / ...
    9h 10m
    $75–110

  4. Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the train from Irving Park to Palatinetrain train
    4h 39m
    $278–714

  5. Fly Lambert–St. Louis International Airport to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago OTC to Palatinetrain train
    4h 52m
    $64–374

  6. Drive to Decatur Airport, fly to Chicago O'Hare International Airport

    1. Drive from St. Louis to Decatur Airport (DEC)car car
    2. Fly from Decatur Airport (DEC) to Chicago O'Hare International Airport (ORD)plane plane DEC - ORD
    5h 27m
    $58–263

  7. Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane plane SPI - ORD
    5h 48m
    $80–310

  8. Fly Lambert–St. Louis International Airport to General Mitchell International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane plane STL - MKE
    2. Take the bus from Mitchell Airport to O'Hare International Airport - Terminal 2 Departuresbus bus
    6h 40m
    $524–902

  9. Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    6h 39m
    $136–317

St. Louis to Palatine by train, foot, and bus

Calendar38Weekly Services
Duration6h 25mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Palatine.ExpandLaunch map view
  • Distance: 308 mi
  • Duration: 6h 25m

What companies run services between St. Louis, MO, USA and Palatine, IL, USA?

You can take a train from St. Louis to Palatine via Chicago Union Station, Washington & Jefferson, Washington & Canal, and Chicago OTC in around 6h 25m. Alternatively, you can take a bus from St Louis Bus Station to Rand/Williams via Champaign Intermodal Trans Ctr, Illinois Terminal, Woodfield Mall, and Northwest Transportation Center in around 9h 10m.

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