There are 2 ways to get from St. Louis to Panama City by plane or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Lambert–St. Louis International Airport (STL) to Tocumen International Airport (PTY) flights
Comparing Your Travel Options
The cheapest way to get from St. Louis to Panama City is to fly which costs $210 - $800 and takes 9h 59m.
The fastest way to get from St. Louis to Panama City is to fly which takes 9h 59m and costs $210 - $800.
The distance between St. Louis and Panama City is 3523 km. The road distance is 5583.9 km.
It takes approximately 9h 59m to get from St. Louis to Panama City, including transfers.
Yes, the driving distance between St. Louis to Panama City is 5584 km. It takes approximately 3 days 0h to drive from St. Louis to Panama City.
There are 870+ hotels available in Panama City.
What companies run services between St. Louis, MO, USA and Panama City, Panama?
Delta, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Tocumen International Airport (PTY) every 4 hours.
- Website
- copaair.com
Flights from Lambert–St. Louis International Airport to Tocumen International Airport via Cancun
- Ave. Duration
- 6h 35m
- When
- Every day
- Estimated price
- $170–750
Flights from Lambert–St. Louis International Airport to Tocumen International Airport via Orlando
- Ave. Duration
- 6h 54m
- When
- Every day
- Estimated price
- $170–750
Flights from Lambert–St. Louis International Airport to Tocumen International Airport via Atlanta
- Ave. Duration
- 7h 4m
- When
- Monday, Tuesday, Thursday, Saturday, and Sunday
- Estimated price
- $170–750
Want to know more about travelling around the world?
Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Need to know: Eurostar, Getting around the Cyclades, and Travelling by boat in Italy - to help you get the most out of your next trip.