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How to get fromSt. Louis to Panama City Beachby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak, Flixbus, Greyhound)

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There are 7 ways to get from St. Louis to Panama City Beach by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak, Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Northwest Florida Beaches International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    3h 44m
    $142–548

  2. Fly Lambert–St. Louis International Airport to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    4h 38m
    $98–488

  3. Bus

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus
    2. Take the bus from Nashville Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    20h 14m
    $143–274

  4. Bus, train

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the train from Carbondale to New Orleans Union Passenger Terminaltrain train
    3. Take the bus from New Orleans Bus Station to Mobile Bus Stationbus bus
    4. Take the bus from Mobile Bus Station to Panama City Beach Bus Stationbus bus
    24h 57m
    $270–573

  5. Drive 748 mi

    1. Drive from St. Louis to Panama City Beachcar car 748 mi
    13h 36m
    $137–198

  6. Fly Midamerica St. Louis Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h
    $100–406

  7. Bus via Atlanta

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    4. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    21h 29m
    $150–303

Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) flights

Calendar31Weekly Planes
Duration2h 57mAverage Duration
Ticket$91Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Panama City Beach.ExpandLaunch map view
  • Distance: 667.5 mi
  • Duration: 3h 44m

What companies run services between St. Louis, MO, USA and Panama City Beach, FL, USA?

Southwest Airlines and Delta fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) 4 times a day. Alternatively, you can take a bus from St Louis Bus Station to Panama City Beach via Nashville Bus Station, Tallahassee, and Panama City Beach Bus Station in around 20h 14m.

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