Rome2Rio

How to get fromSt. Louis to Panama Cityby plane or car

Find Transport to Panama City

See all options

There are 6 ways to get from St. Louis to Panama City by plane or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Northwest Florida Beaches International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    3h 50m
    $158–562

  2. Fly Lambert–St. Louis International Airport to Pensacola International Airport, drive

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    2. Drive from Pensacola-Airport-PNS to Panama Citycar car
    5h 50m
    $96–452

  3. Drive 743.7 mi

    1. Drive from St. Louis to Panama Citycar car 743.7 mi
    13h 31m
    $136–196

  4. Fly Lambert–St. Louis International Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    4h 51m
    $100–490

  5. Fly Midamerica St. Louis Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama Citycar car
    5h 13m
    $102–408

  6. Fly Lambert–St. Louis International Airport to Dothan Regional Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Dothan Regional Airport (DHN)plane plane STL - DHN
    2. Drive from Dothan Regional Airport (DHN) to Panama Citycar car
    6h 58m
    $108–516

Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) flights

Calendar31Weekly Planes
Duration2h 57mAverage Duration
Ticket$91Cheapest Price
See schedules

Questions & Answers

Map of how to get from St. Louis to Panama City.ExpandLaunch map view
  • Distance: 671.8 mi
  • Duration: 3h 50m

What companies run services between St. Louis, MO, USA and Panama City, FL, USA?

Southwest Airlines and Delta fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) 4 times a day.

Airlines

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides