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How to get fromSt. Louis to Pennsylvaniaby plane, bus (Greyhound), train (Amtrak), car, bus, or train

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There are 8 ways to get from St. Louis to Pennsylvania by plane, bus (Greyhound), train (Amtrak), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Philadelphia International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Philadelphia International Airport (PHL)plane plane STL - PHL
    4h 27m
    $126–756

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from St Louis Bus Station to Philadelphia Bus Stationbus bus Greyhound US0421
    22h 25m
    $120–250

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Rockville Amtraktrain train
    3. Take the train from Washington Union Station to 30th Street Stationtrain train
    25h 20m
    $316–703

  4. Drive 879.8 mi

    1. Drive from St. Louis to Philadelphiacar car 879.8 mi
    15h 2m
    $161–232

  5. Fly to Pittsburgh International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Pittsburgh International Airport (PIT)plane plane STL - PIT
    2. Take the bus from Pittsburgh International Airport to Seventh Ave + William Penn Plbus bus
    4h 35m

  6. Fly to Baltimore-Washington International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Baltimore-Washington International Airport (BWI)plane plane STL - BWI
    2. Take the train from BWI Thurgood Marshall to 30th Street Stationtrain train
    5h 56m
    $140–1,258

  7. Fly to Laguardia Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Laguardia Airport (LGA)plane plane STL - LGA
    2. Take the train from Ny Moynihan Train Hall At Penn Station to 30th Street Stationtrain train
    6h 18m
    $168–1,052

  8. Fly to Cleveland-Hopkins International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Cleveland-Hopkins International Airport (CLE)plane plane STL - CLE
    2. Take the bus from Cleveland Bus Station to Eriebus bus
    6h 15m
    $510–936

St. Louis to Pennsylvania by bus (Greyhound)

Calendar21Weekly Buses
Duration22h 25mAverage Duration
Ticket$120Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Pennsylvania.ExpandLaunch map view
  • Distance: 833.7 mi
  • Duration: 4h 27m

What companies run services between St. Louis, MO, USA and Pennsylvania, USA?

American Airlines, Southwest Airlines, and Delta fly from Lambert–St. Louis International Airport (STL) to Philadelphia International Airport (PHL) every 4 hours. Alternatively, Greyhound USA operates a bus from St Louis Bus Station to Philadelphia Bus Station 3 times a day. Tickets cost $120–250 and the journey takes 22h 25m.

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