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How to get fromSt. Louis to Port Saint Lucieby plane, bus, bus (Greyhound, Flixbus), car, train, or bus (Greyhound)

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There are 7 ways to get from St. Louis to Port Saint Lucie by plane, bus, bus (Greyhound, Flixbus), car, train, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Orlando, bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Orlando (MCO)plane plane STL - MCO
    2. Take the bus from Orlando RedCoach Station to Fort Piercebus bus
    7h 6m
    $212–430

  2. Fly Midamerica St. Louis Airport to Orlando Sanford, drive

    cheapest
    1. Fly from Midamerica St. Louis Airport (BLV) to Orlando Sanford (SFB)plane plane BLV - SFB
    2. Drive from Orlando-Sanford-Airport-SFB to Port Saint Luciecar car
    6h 37m
    $134–476

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus FlixBus N2521
    2. Take the bus from Atlanta Bus Station to Port St Luciebus bus FlixBus N2401
    23h 44m
    $174–318

  4. Drive 1,103.3 mi

    1. Drive from St. Louis to Port Saint Luciecar car 1,103.3 mi
    18h 5m
    $202–291

  5. Fly Lambert–St. Louis International Airport to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane STL - FLL
    2. Take the bus from Fort Lauderdale Airport to Fort Piercebus bus
    6h 52m
    $526–1,148

  6. Fly Lambert–St. Louis International Airport to Miami International Airport, train, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Miami International Airport (MIA)plane plane STL - MIA
    2. Take the train from Miami Airport Station to Fort Lauderdale Stationtrain train
    3. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    8h 16m
    $586–998

  7. Bus via Evansville

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Fort Piercebus bus
    29h 39m
    $171–342

St. Louis to Port Saint Lucie by bus

Calendar7Weekly Buses
Duration23h 44mAverage Duration
Ticket$174Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,014.6 mi
  • Duration: 7h 6m

What companies run services between St. Louis, MO, USA and Port Saint Lucie, FL, USA?

You can take a bus from St Louis Bus Station to SW PSL Blvd & Cameo Blvd - East via Atlanta Bus Station and SW Gatlin Blvd & SW Brescia St in around 23h 44m.

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