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How to get fromSt. Louis to Portlandby plane, train, bus, bus (Greyhound, Flixbus, Amtrak), car, or bus (Greyhound, Flixbus)

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There are 6 ways to get from St. Louis to Portland by plane, train, bus, bus (Greyhound, Flixbus, Amtrak), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Portland

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Portland (PWM)plane plane STL - PWM
    6h 8m
    $102–502

  2. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Bostontrain train
    3. Take the bus from Boston, MA - South Station to Portland, MEbus bus
    30h 10m
    $725–1,182

  3. Bus via Boston

    1. Take the bus from St Louis Bus Station to Newark Penn Stationbus bus
    2. Take the bus from Newark Penn Station to Bostonbus bus
    3. Take the bus from Boston, MA - South Station to Portland, MEbus bus
    32h 23m
    $243–388

  4. Drive  1,249.2 mi

    1. Drive from St. Louis to Portlandcar car 1,249.2 mi
    22h 6m
    $214–309

  5. Fly to Boston Logan Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Boston Logan Airport (BOS)plane plane STL - BOS
    2. Take the bus from Logan International Airport to Portland, MEbus bus
    6h 46m
    $486–938

  6. Bus

    1. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus Greyhound US0421
    2. Take the bus from New York Midtown to City of Portlandbus bus FlixBus N2615
    33h 7m
    $243–364

St. Louis to Portland by train and bus

Calendar7Weekly Services
Duration30h 10mAverage Duration
Ticket$725Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to Portland.ExpandLaunch map view
  • Distance: 1,107.1 mi
  • Duration: 6h 8m

What companies run services between St. Louis, MO, USA and Portland, ME, USA?

Southwest Airlines, Delta, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Portland (PWM) every 4 hours. Alternatively, you can take a bus from St Louis Bus Station to Portland, ME via Newark Penn Station, Boston, and Boston, MA - South Station in around 32h 23m.

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Need to know: Greyhound

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