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How to get fromSt. Louis to Prairie du Chienby plane, car, train, or bus

Find Transport to Prairie du Chien

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There are 6 ways to get from St. Louis to Prairie du Chien by plane, car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to La Crosse, drive

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to La Crosse (LSE)plane plane STL - LSE
    2. Drive from La-Crosse-Airport-LSE to Prairie du Chiencar car
    6h 50m
    $88–460

  2. Drive 379.1 mi

    cheapest
    1. Drive from St. Louis to Prairie du Chiencar car 379.1 mi
    7h 1m
    $70–100

  3. Train, bus, drive via Milwaukee

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to UW La Crossebus bus
    4. Drive from UW La Crosse to Prairie du Chiencar car
    13h 17m
    $179–336

  4. Train, bus, drive

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to La Crossebus bus
    4. Drive from La Crosse to Prairie du Chiencar car
    14h 9m
    $162–311

  5. Fly to Minneapolis–Saint Paul International Airport, bus, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    2. Take the bus from St. Paul to La Crossebus bus
    3. Drive from La Crosse to Prairie du Chiencar car
    9h 4m
    $434–1,036

  6. Bus, drive

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to UW La Crossebus bus
    4. Drive from UW La Crosse to Prairie du Chiencar car
    14h 38m
    $124–200

Lambert–St. Louis International Airport (STL) to La Crosse (LSE) flights

Calendar42Weekly Planes
Duration4h 50mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Prairie du Chien.ExpandLaunch map view
  • Distance: 436.8 mi
  • Duration: 6h 50m

What companies run services between St. Louis, MO, USA and Prairie du Chien, WI, USA?

There is no direct connection from St. Louis to Prairie du Chien. However, you can take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to La Crosse (LSE), then drive to Prairie du Chien. Alternatively, you can take a train from St. Louis to Prairie du Chien via Chicago Union Station, Milwaukee, Milwaukee, and UW La Crosse in around 13h 17m.

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