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How to get fromSt. Louis to Roanokeby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Amtrak, Flixbus, Greyhound)

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There are 7 ways to get from St. Louis to Roanoke by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus (Amtrak, Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Roanoke Regional Airport-Woodrum Field

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane STL - ROA
    6h 38m
    $102–508

  2. Bus

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus Greyhound US0186 / ...
    2. Take the bus from Nashville Bus Station to Roanoke Bus Stopbus bus Greyhound US0600
    16h 10m
    $114–221

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Charlottesvilletrain train
    3. Take the train from Charlottesville to Roanoketrain train
    30h 8m
    $388–808

  4. Drive 673.4 mi

    1. Drive from St. Louis to Roanokecar car 673.4 mi
    11h 34m
    $123–178

  5. Fly to Greenbrier Valley Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Greenbrier Valley Airport (LWB)plane plane STL - LWB
    2. Drive from Greenbrier Valley Airport (LWB) to Roanokecar car
    7h 34m
    $114–572

  6. Fly to Lynchburg Regional Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Lynchburg Regional Airport (LYH)plane plane STL - LYH
    2. Take the train from Lynchburg to Roanoketrain train
    9h 29m
    $122–590

  7. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Roanoke Bus Stopbus bus
    16h 20m
    $110–233

St. Louis to Roanoke by bus

Calendar7Weekly Buses
Duration16h 10mAverage Duration
Ticket$114Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Roanoke.ExpandLaunch map view
  • Distance: 595.1 mi
  • Duration: 6h 38m

What companies run services between St. Louis, MO, USA and Roanoke, VA, USA?

American Airlines, Delta, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Roanoke Regional Airport-Woodrum Field (ROA) hourly. Alternatively, you can take a bus from St Louis Bus Station to Roanoke Bus Stop via Nashville Bus Station in around 16h 10m.

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