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How to get fromSt. Louis to Roanokeby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus (Amtrak, Flixbus, Greyhound)

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There are 6 ways to get from St. Louis to Roanoke by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus (Amtrak, Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Roanoke Regional Airport-Woodrum Field

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane STL - ROA
    6h 26m
    $96–478

  2. Bus

    1. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus Greyhound US0186 / ...
    2. Take the bus from Nashville Bus Station to Roanoke Bus Stopbus bus Greyhound US0600
    16h
    $112–238

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Charlottesvilletrain train
    3. Take the train from Charlottesville to Roanoketrain train
    30h 8m
    $316–716

  4. Drive  673.4 mi

    1. Drive from St. Louis to Roanokecar car 673.4 mi
    11h 29m
    $123–178

  5. Fly to Greenbrier Valley Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Greenbrier Valley Airport (LWB)plane plane STL - LWB
    2. Drive from Greenbrier Valley Airport (LWB) to Roanokecar car
    8h 30m
    $104–502

  6. Bus via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Roanoke Bus Stopbus bus
    16h 20m
    $109–231

St. Louis to Roanoke by bus

Calendar7Weekly Buses
Duration16hAverage Duration
Ticket$112Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Roanoke.ExpandLaunch map view
  • Distance: 595.1 mi
  • Duration: 6h 26m

What companies run services between St. Louis, MO, USA and Roanoke, VA, USA?

Delta, American Airlines, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Roanoke Regional Airport-Woodrum Field (ROA) hourly. Alternatively, you can take a bus from St Louis Bus Station to Roanoke Bus Stop via Nashville Bus Station in around 16h.

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