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How to get fromSt. Louis to Roanokeby bus (Greyhound), train, car, or plane

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There are 5 ways to get from St. Louis to Roanoke by bus (Greyhound), train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis, IN to Fort Wayne, INbus bus Cincinnati
    7h 58m
    $94–179

  2. Drive 340.8 mi

    cheapest
    1. Drive from St. Louis to Roanokecar car 340.8 mi
    6h 20m
    $63–90

  3. Train, drive (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Elkhart Amtrak Stationtrain train
    3. Drive from Elkhart Amtrak Station to Roanokecar car
    9h 34m
    $132–274

  4. Fly

    1. Fly from Lambert–St. Louis International Airport (STL) to Fort Wayne International Airport (FWA)plane plane STL - FWA
    5h 18m
    $108–468

  5. Bus via Indianapolis (Greyhound)

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Ft Wayne Citilink Central Stationbus bus Greyhound US0112
    8h 3m
    $100–164

Lambert–St. Louis International Airport (STL) to Fort Wayne International Airport (FWA) flights

Calendar114Weekly Planes
Duration5h 9mAverage Duration
Ticket$71Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Roanoke.ExpandLaunch map view
  • Distance: 381.5 mi
  • Duration: 7h 58m

What companies run services between St. Louis, MO, USA and Roanoke, IN, USA?

You can take a bus from St Louis Bus Station to Roanoke via Indianapolis, IN and Fort Wayne, IN in around 7h 58m. Alternatively, American Airlines, United Airlines, and Delta fly from Lambert–St. Louis International Airport (STL) to Fort Wayne International Airport (FWA) hourly.

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