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How to get fromSt. Louis to Saint Charlesby train (Amtrak), bus (Flixbus), car, plane, bus, or train

Find Transport to Saint Charles

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There are 7 ways to get from St. Louis to Saint Charles by train (Amtrak), bus (Flixbus), car, plane, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago OTC to Genevatrain train Up-W
    6h 52m
    $110–210

  2. Drive 277.6 mi

    cheapest
    1. Drive from St. Louis to Saint Charlescar car 277.6 mi
    5h 5m
    $51–74

  3. Bus

    1. Take the bus from St Louis Bus Station to Champaign Intermodal Trans Ctrbus bus FlixBus N2521 / ...
    2. Take the bus from Illinois Terminal to Oakbrook Mallbus bus Champaign to Chicago ends at Woodfield NB / ...
    9h 17m
    $116–161

  4. Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the bus from Rosemont CTA Station to Elgin Transportation Center Bay 4bus bus
    4h 41m
    $306–756

  5. Fly Lambert–St. Louis International Airport to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago OTC to Genevatrain train
    5h 19m
    $76–400

  6. Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport, bus

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane plane SPI - ORD
    3. Take the bus from Rosemont CTA Station to Elgin Transportation Center Bay 4bus bus
    5h 51m
    $108–363

  7. Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport, bus

    1. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    3. Take the bus from Rosemont CTA Station to Elgin Transportation Center Bay 4bus bus
    6h 32m
    $159–359

Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD) flights

Calendar102Weekly Planes
Duration1h 33mAverage Duration
Ticket$47Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Saint Charles.ExpandLaunch map view
  • Distance: 319.9 mi
  • Duration: 6h 52m

What companies run services between St. Louis, MO, USA and Saint Charles, IL, USA?

You can take a train from St. Louis to Saint Charles via Chicago Union Station, Washington & Jefferson, Washington & Canal, Chicago OTC, and Geneva in around 6h 52m. Alternatively, you can take a bus from St Louis Bus Station to Saint Charles via Champaign Intermodal Trans Ctr, Illinois Terminal, Oak Brook Center / Macy's, and Wheaton Metra in around 9h 17m.

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