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How to get fromSt. Louis to Salisburyby plane, train, bus (Flixbus, Amtrak, Greyhound), train (Amtrak), car, bus (Greyhound, Flixbus), or bus

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There are 8 ways to get from St. Louis to Salisbury by plane, train, bus (Flixbus, Amtrak, Greyhound), train (Amtrak), car, bus (Greyhound, Flixbus), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charlotte Douglas International Airport, train

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Charlotte Douglas International Airport (CLT)plane plane STL - CLT
    2. Take the train from Charlotte Amtrak Station to Salisbury Amtrak Stationtrain train
    6h 12m
    $140–736

  2. Drive 689.6 mi

    cheapest
    1. Drive from St. Louis to Salisburycar car 689.6 mi
    13h 19m
    $126–182

  3. Bus via Carbondale

    1. Take the bus from St Louis Bus Station to Carbondale Intermodal Stationbus bus
    2. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Salisburybus bus
    17h 37m
    $135–263

  4. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Salisbury Amtrak Stationtrain train
    33h 33m
    $465–1,020

  5. Fly to Piedmont Triad International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Piedmont Triad International Airport (GSO)plane plane STL - GSO
    2. Take the train from High Point to Salisbury Amtrak Stationtrain train
    8h 14m
    $182–848

  6. Fly to Raleigh-Durham International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)plane plane STL - RDU
    2. Take the train from Durham Amtrak Station to Salisbury Amtrak Stationtrain train
    7h 43m
    $588–1,078

  7. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Salisburybus bus Greyhound US0670
    18h 22m
    $135–258

  8. Bus, train

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Charlotte Bus Stationbus bus
    3. Take the train from Charlotte Amtrak Station to Salisbury Amtrak Stationtrain train
    18h 31m
    $135–264

St. Louis to Salisbury by train (Amtrak)

Calendar7Weekly Trains
Duration33h 33mAverage Duration
Ticket$465Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Salisbury.ExpandLaunch map view
  • Distance: 639.3 mi
  • Duration: 6h 12m

What companies run services between St. Louis, MO, USA and Salisbury, NC, USA?

You can take a bus from St Louis Bus Station to Salisbury via Carbondale Intermodal Station, Atlanta Bus Station, and Salisbury in around 17h 37m. Alternatively, you can take a train from St. Louis to Salisbury Amtrak Station via Chicago Union Station and Cary in around 33h 33m.

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