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How to get fromSt. Louis to San Diegoby plane, train (Amtrak), bus (Greyhound, Flixbus), or car

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There are 5 ways to get from St. Louis to San Diego by plane, train (Amtrak), bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN)plane plane STL - SAN
    5h 26m
    $132–192

  2. Train via Kansas City (Amtrak)

    1. Take the train from St. Louis to Kansas Citytrain train
    2. Take the train from Kansas City to Fullerton Amtrak Stationtrain train
    3. Take the train from Fullerton Amtrak Station to San Diegotrain train
    44h 53m
    $1,158–1,825

  3. Bus

    1. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus Greyhound US1210
    2. Take the bus from Los Angeles Downtown to San Diegobus bus FlixBus 2017
    45h
    $371–548

  4. Drive  1,797.7 mi

    1. Drive from St. Louis to San Diegocar car 1,797.7 mi
    29h 11m
    $308–444

  5. Train (Amtrak)

    1. Take the train from St. Louis to Los Angelestrain train Texas Eagle
    2. Take the train from Los Angeles to San Diegotrain train Pacific Surfliner
    2d 15h
    $1,402–2,161

St. Louis to San Diego by train (Amtrak)

Calendar7Weekly Trains
Duration44h 53mAverage Duration
Ticket$1,158Cheapest Price
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Comparing Your Travel Options

Map of how to get from St. Louis to San Diego.ExpandLaunch map view
  • Distance: 1,568.7 mi
  • Duration: 5h 26m

What companies run services between St. Louis, MO, USA and San Diego, CA, USA?

Southwest Airlines, United Airlines, and American Airlines fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN) every 4 hours. Alternatively, you can take a train from St. Louis to San Diego via Kansas City and Fullerton Amtrak Station in around 44h 53m.

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Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

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