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How to get fromSt. Louis to San Diegoby plane, bus (Greyhound, Amtrak), train (Amtrak), car, train, or bus

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There are 5 ways to get from St. Louis to San Diego by plane, bus (Greyhound, Amtrak), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN)plane plane STL - SAN
    5h 11m
    $132–192

  2. Bus

    1. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus Greyhound US1210
    2. Take the bus from Los Angeles to San Diegobus bus Amtrak Thruway Connecting Service
    42h 50m
    $345–639

  3. Train (Amtrak)

    1. Take the train from St. Louis to Kansas Citytrain train
    2. Take the train from Kansas City to Fullerton Amtrak Stationtrain train
    3. Take the train from Fullerton Amtrak Station to San Diegotrain train
    44h 53m
    $671–1,452

  4. Drive 1,797.7 mi

    1. Drive from St. Louis to San Diegocar car 1,797.7 mi
    29h 11m
    $329–474

  5. Train, bus

    1. Take the train from St. Louis to Yuma Amtraktrain train
    2. Take the bus from 3rd Street @ Gila Street to William Brook Ave @ B Streetbus bus 95
    3. Take the bus from San Luis Río Colorado to Tijuanabus bus
    2d 15h
    $736–1,506

St. Louis to San Diego by bus and foot

Calendar7Weekly Services
Duration42h 50mAverage Duration
Ticket$345Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to San Diego.ExpandLaunch map view
  • Distance: 1,568.7 mi
  • Duration: 5h 11m

What companies run services between St. Louis, MO, USA and San Diego, CA, USA?

Southwest Airlines and American Airlines fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN) 5 times a day. Alternatively, you can take a bus from St Louis Bus Station to San Diego via Los Angeles Union Station and Los Angeles in around 42h 50m.

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