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How to get fromSt. Louis to Sanfordby plane, train, bus (Greyhound, Flixbus), train (Amtrak), or car

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There are 5 ways to get from St. Louis to Sanford by plane, train, bus (Greyhound, Flixbus), train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Orlando, train

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Orlando (MCO)plane plane STL - MCO
    2. Take the train from Sand Lake Road to Sanfordtrain train
    6h 2m
    $188–380

  2. Train to Midamerica St. Louis Airport, fly to Orlando Sanford

    cheapest
    1. Take the train from CIVIC CENTER station to SHILOH-SCOTT stationtrain train
    2. Fly from Midamerica St. Louis Airport (BLV) to Orlando Sanford (SFB)plane plane BLV - SFB
    4h 7m
    $106–450

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus Greyhound US0186
    2. Take the bus from Atlanta Bus Station to Orlando Bus Stationbus bus FlixBus N2401 / ...
    22h 26m
    $153–295

  4. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Delandtrain train Floridian
    44h 24m
    $590–1,288

  5. Drive 983.8 mi

    1. Drive from St. Louis to Sanfordcar car 983.8 mi
    16h 41m
    $180–260

St. Louis to Sanford by bus and train

Calendar24Weekly Services
Duration22h 26mAverage Duration
Ticket$153Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Sanford.ExpandLaunch map view
  • Distance: 930 mi
  • Duration: 6h 2m

What companies run services between St. Louis, MO, USA and Sanford, FL, USA?

You can take a bus from St Louis Bus Station to Sanford via Atlanta Bus Station, Orlando Bus Station, John Young Pkwy & Amelia St, N Garland Ave & W Amelia St, and LYNX Central in around 22h 26m. Alternatively, you can take a train from St. Louis to Sanford via Chicago Union Station and DeLand in around 44h 24m.

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