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How to get fromSt. Louis to Sanibelby plane, bus (Greyhound, Flixbus), car, bus, or train

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There are 4 ways to get from St. Louis to Sanibel by plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Ft. Myers (RSW)plane plane STL - RSW
    4h 38m
    $202–738

  2. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Tampa Bus Stationbus bus
    3. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    25h 38m
    $211–360

  3. Drive  1,125 mi

    1. Drive from St. Louis to Sanibelcar car 1,125 mi
    19h 29m
    $206–297

  4. Bus, train

    1. Take the bus from St Louis Bus Station to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    3. Take the bus from Gulfport to Fort Myersbus bus
    33h 39m
    $297–453

Lambert–St. Louis International Airport (STL) to Ft. Myers (RSW) flights

Calendar54Weekly Planes
Duration3h 52mAverage Duration
Ticket$133Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Sanibel.ExpandLaunch map view
  • Distance: 1,019 mi
  • Duration: 4h 38m

What companies run services between St. Louis, MO, USA and Sanibel, FL, USA?

Southwest Airlines and Delta fly from Lambert–St. Louis International Airport (STL) to Ft. Myers (RSW) every 4 hours. Alternatively, you can take a bus from St Louis Bus Station to Sanibel via Atlanta Bus Station, Tampa Bus Station, and Fort Myers Bus Stop in around 25h 38m.

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