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How to get fromSt. Louis to Sanibel Islandby plane, bus (Greyhound, Flixbus), car, bus, or train

Find Transport to Sanibel Island

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There are 4 ways to get from St. Louis to Sanibel Island by plane, bus (Greyhound, Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Ft. Myers (RSW)plane plane STL - RSW
    4h 36m
    $208–742

  2. Drive 1,124 mi

    cheapest
    1. Drive from St. Louis to Sanibel Islandcar car 1,124 mi
    19h 27m
    $206–297

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to University of South Floridabus bus
    3. Take the bus from University of South Florida - 3801 USF Holly Dr to Fort Myers 7-11bus bus
    24h 45m
    $256–448

  4. Bus, train

    1. Take the bus from St Louis Bus Station to New Orleans Bus Stationbus bus
    2. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    3. Take the bus from Gulfport to Fort Myersbus bus
    33h 37m
    $309–474

Lambert–St. Louis International Airport (STL) to Ft. Myers (RSW) flights

Calendar62Weekly Planes
Duration3h 58mAverage Duration
Ticket$132Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Sanibel Island.ExpandLaunch map view
  • Distance: 1,017.9 mi
  • Duration: 4h 36m

What companies run services between St. Louis, MO, USA and Sanibel Island, FL, USA?

Southwest Airlines, Delta, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Ft. Myers (RSW) every 3 hours. Alternatively, you can take a bus from St Louis Bus Station to Sanibel Island via Atlanta Bus Station, University of South Florida - 3801 USF Holly Dr, and Fort Myers 7-11 in around 24h 45m.

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